194918-76-8 Usage
Uses
Used in Pharmaceutical Industry:
ACPT-I is used as a neuroprotective agent for reducing cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion. Its neuroprotective properties make it a promising candidate for the development of treatments for neurological disorders and conditions involving cell death and damage.
Used in Neurological Research:
ACPT-I is used as an anticonvulsant agent for reducing the incidence of clonic seizures in various seizure models in mice and rats. Its anticonvulsant properties make it a valuable tool for studying the mechanisms underlying seizure activity and for developing new treatments for epilepsy and other seizure disorders.
Used in Anxiety Research:
ACPT-I is used as an anxiolytic-like agent for studying the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor in anxiety. Its anxiolytic-like effects, which can be blocked by WAY-100635 and flumazenil, make it a useful tool for understanding the neural pathways and receptors involved in anxiety and for developing new treatments for anxiety disorders.
Used in Neurodegenerative Disease Research:
ACPT-I is used as a neuroprotective agent against excitotoxicity induced by kainite in vitro and in vivo. Its neuroprotective properties make it a valuable tool for studying the mechanisms underlying neurodegenerative diseases and for developing new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and other related disorders.
Biological Activity
Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.
Check Digit Verification of cas no
The CAS Registry Mumber 194918-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,9,1 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 194918-76:
(8*1)+(7*9)+(6*4)+(5*9)+(4*1)+(3*8)+(2*7)+(1*6)=188
188 % 10 = 8
So 194918-76-8 is a valid CAS Registry Number.
194918-76-8Relevant academic research and scientific papers
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: New tools to discriminate between metabotropic glutamate receptor subtypes
Acher, Francine C.,Tellier, Frédérique J.,Azerad, Robert,Brabet, Isabelle N.,Fagni, Laurent,Pin, Jean R.
, p. 3119 - 3129 (2007/10/03)
The four stereoisomers of 1-aminocyclopentane-1,3,4-tricarboxylic acid {ACPT-I (18) and -II (19), (3R,4R)-III [(-)-20], and (3S,4S)-III [(+)-20]} have been synthesized and evaluated for their effects at glutamate receptors subtypes. ACPTs are ACPD analogues in which a third carboxylic group has been added at position 4 in the cyclopentane ring. None of the ACPT isomers showed a significant effect on ionotropic NMDA, KA, and AMPA receptors. On the other hand, ACPT-III (19) was found to be a general competitive antagonist for metabotropic receptors (mGluRs) and exhibited a similar affinity for mGluR1a (K(B) = 115 ± 2 μM), mGluR2 (K(B) = 88 ± 21 μM), and mGluR4a (K(B) = 77 ± 9 μM), the representative members of group I, II and III mGluRs, respectively. Two other isomers, ACPT-I (18) and (+)-(3S,4S)-ACPT-III [(+)- 20], were potent agonist at the group III receptors mGluR4a (EC50 = 7.2 ± 2.3 and 8.8 ± 3.2 μM) and competitive antagonists with low affinity for mGluR1a and mGluR2 (K(B) > 300 μM). Finally, (-)-(3R,4R)-ACPT-III [(-)-20] was a competitive antagonist with poor but significant affinity for mGluR4a (K(B) = 220 μM). These results demonstrate that the addition of a third carboxylic group to ACPD can change its activity (from agonist to antagonist) and either increase or decrease its selectivity and/or affinity for the various mGluR subtypes.
