194920-62-2

Usage

Uses

Used in Pharmaceutical Industry:
BOC-TOTA is used as a reactant in the synthesis of gallium-labeled PET imaging agents for CXCR4, which are essential for potential cancer diagnosis. Its unique structure allows for the development of targeted imaging agents that can help in the early detection and monitoring of cancer progression.
Used in Chemical Synthesis:
BOC-TOTA is used as a protected linker in chemical synthesis, particularly in the formation of complex molecules and drug candidates. The Boc-protected amino group ensures that the molecule can be selectively deprotected under mild acidic conditions, allowing for the controlled formation of amide bonds and other functional groups without unwanted side reactions.
Used in Drug Delivery Systems:
BOC-TOTA can be employed in the development of drug delivery systems, where its Boc-protected amino group can be utilized to attach drug molecules or targeting ligands to carriers, such as nanoparticles or liposomes. The mild acidic conditions required for Boc deprotection can be tailored to match the acidic environment of tumor tissues, enabling targeted drug release and improved therapeutic outcomes.

Upstream product

• 871487-56-8 2-nitro-1,4-di[1-(13-tert-butoxycarbonylamino-4,7,10-trioxatridecanylaminocarbonyloxy)ethyl]benzene 
• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 454445-43-3 {3-nitro-5-[3-(2-{2-[3-(t-Boc-amino)propoxy]ethoxy}ethoxy)propylaminocarbonyl]phenyl}-α-D-galactopyranoside 
• 250612-31-8 3-(N-(3-(2-(2-(3-((tert-butoxy)-carbonylamino)propoxy)ethoxy)ethoxy)propyl)carbamoyl)-propanoic acid 
• 801239-74-7 3-[(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propylamino)-methyl]-4-fluoro-benzoic acid tert-butyl ester 
• 908020-34-8 [3-(2-{2-[3-(4-benzoyl-benzylamino)-propoxy]-ethoxy}-ethoxy)-propyl]-carbamic acid tert-butyl ester 
• 194920-66-6 N,N',N'-tris-(13-N-Boc-4,7,10-trioxatridecanyl)benzene-1,3,5-tricarboxyamide 
• 1034341-79-1 C₃₁H₅₂N₂O₁₂S₂ 
• 1034341-85-9 C₃₀H₅₀N₂O₁₁ 
• 1220998-81-1 C₃₇H₅₀N₂O₆S 
• 1224728-10-2 tert-butyl (1-(4-(chloromethyl)phenyl)-1-oxo-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate 
• 1354746-89-6 C₃₆H₄₂N₂O₁₁ 
• 1233963-32-0 C₆₈H₉₀N₈O₁₈ 
• 1233970-46-1 C₃₂H₅₅N₅O₇ 
• 1246010-46-7 C₃₁H₅₁N₃O₁₀ 
• 1392497-99-2 C₃₈H₆₀N₈O₁₁ 

Relevant academic research and scientific papers

Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines

A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.

Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers

Conjugationally extended hydrazine compositions of the formula (RR2)N(H)n(NH2)n, fluorescent hydrazone compositions of the formula (RR2)NN═C(R1R2), methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls and methods of their use in assays systems are described. Use of these conjugationally extended hydrazine and oxime compositions for direct calorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule. More specifically the linker comprises one molecule of a high affinity binding pair such as for example biotin of the biotin/avidin high affinity binding pair, connected to a spacer molecule such as for example a length of polyethyleneglycol followed by a pro-chromophoric, chromophoric, pro-fluorescent or fluorescent moiety connected to an amino-, thiol- or carbohydrate-reactive moiety such as for example succinimidyl, maleimido or aminoxy group respectively, that may covalently link to a biomolecule.

Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics

Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for construc