194920-73-5Relevant articles and documents
Self-Assembled Vesicle–Carbon Nanotube Conjugate Formation through a Boronate–Diol Covalent Linkage
Dinda, Soumik,Mandal, Deep,Sarkar, Saheli,Das, Prasanta Kumar
, p. 15194 - 15202 (2017)
A vesicle–single walled carbon nanotube (CNT) conjugate was developed by a boronic acid–diol covalent linkage between a self-assembled vesicle and dispersed CNT. Trimesic acid based phenylboronic acid appended triple-tailed amphiphiles (T1 and T1S) were synthesized that formed monolayered vesicles through H-aggregation in DMSO–water (2:1 v/v) and pure water, respectively. Aqueous CNT dispersion was prepared with cholesterol-based glucose-functionalized amphiphile (D1). These two supramolecular self-assemblies were covalently linked by using a boronic acid–diol interaction between a phenylboronic acid based T1S vesicle and 1,2-diol moieties of glucose tethered dispersing agent (D1) to develop a vesicle–CNT conjugate. Lewis acid–base chemistry was exploited to form this boronate–diol adduct between two supramolecular self-assemblies. The formation of vesicles, CNT dispersion, and the vesicle–CNT conjugate was characterized by microscopic and spectroscopic techniques. Anticancer drug doxorubicin was encapsulated within this T1S-vesicle–D1-CNT conjugate with a higher loading capacity compared to the individual cargo carrier (vesicle or CNT). This cytocompatible T1S-vesicle–D1-CNT conjugate successfully delivered loaded doxorubicin within a B16F10 melanoma cell and also exhibited better cellular transportation ability compared to the drug-loaded vesicle or CNT. This was further reflected in an enhanced killing efficiency of the cancer cells by the vesicle–CNT conjugate compared to the drug-loaded vesicle or CNT.
Self-assembly of one- And two-dimensional hemoprotein systems by polymerization through heme-heme pocket interactions
Kitagishi, Hiroaki,Kakikura, Yasuaki,Yamaguchi, Hiroyasu,Oohora, Koji,Harada, Akira,Hayashi, Takashi
, p. 1271 - 1274 (2009)
Supramolecular protein polymers: When a heme moiety was introduced to the surface of an apo-cytochrome b562(H63C) mutant, supramolecular polymers formed through noncovalent heme-heme pocket interactions. The incorporation of a heme triad as a p
Versatile C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer
Berthelmann, Arne,Lach, Johannes,Graewert, Melissa A.,Groll, Michael,Eichler, Jutta
, p. 2606 - 2614 (2014/04/17)
C3-Symmetric trimesic acid scaffolds, functionalized with bromoacetyl, aminooxyacetyl and azidoacetyl moieties, respectively, were synthesized and compared regarding their utility for the trivalent presentation of peptides using three different
Synthesis and conformational analysis of novel trimeric maleimide cross-linking reagents
Szczepanska, Agnieszka,Espartero, Jose Luis,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Remmert, Sarah,Parish, Carol
, p. 6776 - 6785 (2008/02/12)
(Figure Presented) Nine homotrifunctional cross-linking reagents are presented. Their synthesis and chemical properties as well as their characterization by classical mechanical conformational searching techniques is reported. Mixed Low Mode and Monte Car
Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins
Li, Hengguang,Guan, Yongjun,Szczepanska, Agnieszka,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Lewis, George K.,Wang, Lai-Xi
, p. 4220 - 4228 (2008/03/12)
A series of trivalent CD4-mimetic miniproteins was synthesized, in which three CD4M9 miniprotein moieties were tethered on a threefold-symmetric scaffold. The trivalent miniproteins were designed to target the CD4-binding sites displayed in the trimeric g
