194996-01-5Relevant articles and documents
Bioinspired Design Provides High-Strength Benzoxazine Structural Adhesives
Higginson, Cody J.,Malollari, Katerina G.,Xu, Yunqi,Kelleghan, Andrew V.,Ricapito, Nicole G.,Messersmith, Phillip B.
supporting information, p. 12271 - 12279 (2019/08/01)
A synthetic strategy to incorporate catechol functional groups into benzoxazine thermoset monomers was developed, leading to a family of bioinspired small-molecule resins and main-chain polybenzoxazines derived from biologically available phenols. Lap-she
Higher order iminodiacetic acid libraries for probing protein-protein interactions
Boger, Dale L.,Goldberg, Joel,Jiang, Weiqin,Chai, Wenying,Ducray, Pierre,Lee, Jae Kyoo,Ozer, Rachel S.,Andersson, Carl-Magnus
, p. 1347 - 1378 (2007/10/03)
Full details of the preparation of iminodiacetic acid diamide dimer (2040 compounds), trimer (560 compounds), and tetramer (1596 compounds) libraries by multistep convergent solution-phase synthesis for studying protein-protein interactions are provided. The libraries were assembled in a format providing small 8-10 compound mixtures and the deconvolution of many of the small mixtures to identify screening leads by resynthesis of the individual components have been conducted for 320 of the individual compounds to date. A representative example of the subsequent exploration of the structure-activity relationships for an identified receptor binding antagonist (200 additional individual compounds) and steps taken for potential elaboration to a receptor dimerization agonist are defined with preparation of representative linked dimers (70 compounds). Copyright (C) 1998 Elsevier Science Ltd.