195005-08-4

Basic information

• Product Name: 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide
• Synonyms: 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide
• CAS NO: 195005-08-4
• Molecular Weight: 486.345
• Mol File: 195005-08-4.mol

Chemical Properties

• CAS DataBase Reference: 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide(195005-08-4)
• EPA Substance Registry System: 2-Bromo-N-(diphenyl-phosphinoylmethyl)-N-methyl-5-propoxy-benzamide(195005-08-4)

Safety Data

• Hazardous Substances Data: 195005-08-4(Hazardous Substances Data)

Upstream product

• 195005-37-9 2-bromo-5-propoxybenzaldehyde 
• 122365-23-5 N-[(diphenylphosphinoyl)methyl]-N-methylamine 

Relevant articles and documents

An efficient one-pot synthesis of 3-(aryl and alkyl)methylene-1H-isoindolin-1-ones via aryne cyclization and horner reaction of o-(and m-) halogeno-N-phosphorylmethylbenzamide derivatives

A series of 3-(alkyl and aryl)methylene-2,3-dihydro-1H-isoindol-1-one derivatives was synthesized by a one-pot reaction sequence involving lithiation of 2- (or 3-)halogeno-N-phosphoryl-methylbenzamides, cyclization of the aryne intermidiate, metal migration and Horner reaction of the resulting phosphorylated aminocarbanion with selected aromatic and aliphatic aldehydes.

A short and efficient synthesis of 3-diphenylphosphoryl- and 3-diethoxyphosphoryl(aza)isoindolinones: Extension to the sulfonylated analogs

A variety of 3-diphenylphosphoryl- and 3-diethoxyphosphoryl(aza)isoindolinones have been efficiently prepared by aryne- and hetaryne-mediated cyclization of phosphorylated α-amino carbanions derived from suitably substituted 2- and 3-halobenzamide and 3-chloropyridine-4-carboxamide derivatives. The synthesis of some 3-sulfonylated analogs by extension of this principle has been achieved.