195060-54-9

Upstream product

• 195060-51-6 Methyl 4-iodo-3-[2-oxo-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethoxy]-benzoate 
• 132392-28-0 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one 
• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Relevant academic research and scientific papers

Benzofuran-acrylic acid derivatives and their use as modulators of RXRs or RARs receptors

PCT No. PCT/FR97/02205 Sec. 371 Date Oct. 13, 1998 Sec. 102(e) Date Oct. 13, 1998 PCT Filed Dec. 4, 1997 PCT Pub. No. WO98/24778 PCT Pub. Date Jun. 11, 1998The present invention provides novel heteroaryl compounds having the general formula (I): their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respiratory, cardiovascular and ophthalmologic conditions, and their use in cosmetic compositions.

New synthetic retinoids obtained by palladium-catalyzed tandem cyclisation-hydride capture process

A new series of conformationally restricted retinoids (3-aryl-3-methyl- 2,3-dihydrobenzofurans) have been prepared through a palladium-catalyzed tandem cyclisation-hydride capture. The use of enantiopure BINAP-Pd catalyst allowed asymmetric synthesis of bioactive molecules.