195061-59-7Relevant academic research and scientific papers
Enantioselective catalysis, 109 [1] new expanded chiral bipyridines
Brunner, Henri,Poleschak, Ingo
, p. 839 - 846 (2007/10/03)
Optically active two and three layer nitrogen ligands were synthesized by reacting the N-BOC-protected aminoalcohols (1S,2S)-2-amino-1-phenyl-1,3-propanediol and (S)-2-amino-1,4-butanediol with chloromethyl-benzoic acid chlorides. Expansion was carried out at the chloromethyl substituents via nucleophilic substitution with N-methylated (R)-1-phenylethylamine. The deprotected substances were N-benzylated and reacted with 6,6′-bis(bromomethyl)-2,2′-bipyridine to give the new optically active expanded bipyridine ligands.
