19508-69-1

Upstream product

• 81127-23-3 5-[1,3]Dioxolan-2-ylmethyl-piperidin-3-ol 
• 81127-25-5 benzyl 3-hydroxy-5-(2-oxoethyl)piperidine-1-carboxylate 
• 81127-29-9 benzyl (E)-9-(3-ethoxycarbonyl-2-propenyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate 
• 104-15-4 toluene-4-sulfonic acid 
• 81127-39-1 endo-7-ethyl-2-(3-indolylacetyl)-6,6-dimethoxy-2-azabicyclo<2.2.2>octane 
• 81127-22-2 ethyl 5-(2-ethylenedioxyethyl)-3-hydroxypiperidine-1-carboxylate 
• 81127-32-4 (1R,4S,7S)-7-Ethyl-2-aza-bicyclo[2.2.2]octan-6-one 
• 81127-27-7 benzyl (E)-5-(3-ethoxycarbonyl-2-propenyl)-3-oxopiperidine-1-carboxylate 
• 81127-24-4 benzyl 5-(1,3-dioxolan-2-ylmethyl)-3-hydroxypiperidine-1-carboxylate 
• 81127-26-6 benzyl (E)-5-(3-ethoxycarbonyl-2-propenyl)-3-hydroxypiperidine-1-carboxylate 
• 81127-28-8 benzyl 9-(2-oxoethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate 
• 81127-39-1 1-((1R,4S,7S)-7-Ethyl-6,6-dimethoxy-2-aza-bicyclo[2.2.2]oct-2-yl)-2-(1H-indol-3-yl)-ethanone 
• 81127-32-4 (1R,4S,7R)-7-Ethyl-2-aza-bicyclo[2.2.2]octan-6-one 
• 81127-39-1 1-((1R,4S,7R)-7-Ethyl-6,6-dimethoxy-2-aza-bicyclo[2.2.2]oct-2-yl)-2-(1H-indol-3-yl)-ethanone 

Downstream Products

• 481-87-8 (+/-)-epi-ibogamine 
• 481-87-8 (+/-)-epiibogamine 
• 481-87-8 (+/-)-ibogamine 

Relevant academic research and scientific papers

1,6-dihydro-3(2H)-pyridinones. X. 2-azabicyclooctane Ring Formation via Intramolecular Michael reaction: Total synthesis of (+/-)-Ibogamine and (+/-)-Epiibogamine

A new elaboration method for the 2-azabicyclooctane ring via an intramolecular Michael reaction has been developed and applied to the total synthesis of (+/-)-ibogamine (1) and (+/-)-epiibogamine (2).The unsaturated estert (9) derived from ethyl 1,