1952-36-9Relevant academic research and scientific papers
Directed Amination of Aryl Methyl Ethers Mediated by Ti(NMe2)4 at Room Temperature
Chen, Zhou,Liu, Jinna,Pei, Hao,Liu, Wei,Chen, Yanmei,Wu, Jian,Li, Wu,Li, Yahong
, p. 3406 - 3409 (2015)
An efficient C-O amination of aryl methyl ethers has been achieved. This transformation proceeds via imine-directed Ti(IV)-mediated cross-coupling reactions between aryl methyl ethers and Ti(NR2)4 at room temperature, straightforwardly leading to a series of arylamines. This protocol features a wide substrate scope, exclusive regioselectivity, and mild reaction conditions.
