195203-89-5Relevant academic research and scientific papers
Synthesis of pyranose glycals via tungsten and molybdenum pentacarbonyl-induced alkynol cyclizations
McDonald, Frank E.,Zhu, Hugh Y. H.
, p. 11061 - 11068 (2007/10/03)
The tungsten pentacarbonyl-induced cyclization of an acyclic alkynol substrate bearing protected oxygen and nitrogen functional groups provides the cyclic tungsten oxacarbene, which is readily converted into a pyranose glycal structurally related to the carbohydrate moieties of the pluramycin and vancomycin families of antitumor antibiotics. In addition a molybdenum-catalyzed cycloisomerization procedure provides an alternative route to this pyranose glycal.
