195204-06-9Relevant academic research and scientific papers
Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
Tamura, Susan Y.,Semple, J. Edward,Reiner, John E.,Goldman, Erick A.,Brunck, Terence K.,Lim-Wilby, Marguerita S.,Carpenter, Stephen H.,Rote, William E.,Oldeshulte, Gerard L.,Richard, Brigitte M.,Nutt, Ruth F.,Ripka, William C.
, p. 1543 - 1548 (2007/10/03)
Several potent and selective inhibitors of thrombin incorporating novel heterocyclic peptide surrogates in the P3-P2 position of peptidyl argininals have been discovered. Illustrated in this article are three classes of heterocycles: pyridones, uracils, and pyrimidinones. The synthesis and biological activities of these unique aromatic heterocyclic derivatives are reported herein.
