195244-32-7Relevant academic research and scientific papers
Fast atom bombardment-promoted reductive ring opening of 1,2-benzisothiazoles
Sharp, Thomas R.,Lambert, John F.,Walinsky, Stanley W.
, p. 2117 - 2120 (2003)
Fast atom bombardment mass spectral examination of molecules containing a 1,2-benzisothiazole ring, using a thiol reducing agent matrix, promotes reductive ring opening of the benzisothiazole ring, giving an [M+H]+ two daltons higher than expected. Measurements using a non-reducing matrix produce the expected [M+H]+. This is a general phenomenon, observed with a number of molecules containing the benzisothiazole ring. The ring-opened structure has been confirmed by chemical synthesis and observed in metabolic studies.
Pro-drugs of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
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, (2008/06/13)
The present invention relates to a pro-drug of ziprasidone or pharmaceutically acceptable salts thereof, processes for its preparation, and pharmaceutical compositions and methods of treatment comprising said pro-drug.
