195244-32-7Relevant articles and documents
Fast atom bombardment-promoted reductive ring opening of 1,2-benzisothiazoles
Sharp, Thomas R.,Lambert, John F.,Walinsky, Stanley W.
, p. 2117 - 2120 (2003)
Fast atom bombardment mass spectral examination of molecules containing a 1,2-benzisothiazole ring, using a thiol reducing agent matrix, promotes reductive ring opening of the benzisothiazole ring, giving an [M+H]+ two daltons higher than expected. Measurements using a non-reducing matrix produce the expected [M+H]+. This is a general phenomenon, observed with a number of molecules containing the benzisothiazole ring. The ring-opened structure has been confirmed by chemical synthesis and observed in metabolic studies.
