195244-48-5

Upstream product

• 195244-47-4 (3S,4R,5S)-4-Acetylamino-5-azido-2-chloro-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 5188-07-8 sodium thiomethoxide 
• 195244-42-9 (1S,5S,6S)-4-Chloro-5-(1-ethyl-propoxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester 
• 195244-45-2 (1R,5S,6R)-4-Chloro-5-(1-ethyl-propoxy)-7-aza-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester 
• 195244-44-1 (3S,4S,5R)-5-Azido-2-chloro-3-(1-ethyl-propoxy)-4-methanesulfonyloxy-cyclohex-1-enecarboxylic acid methyl ester 
• 195244-40-7 (3aS,7R,7aR)-4-Chloro-2,2-diethyl-7-methanesulfonyloxy-3a,6,7,7a-tetrahydro-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 221387-32-2 (3aS,7R,7aR)-4-Chloro-7-methanesulfonyloxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 195244-43-0 (3S,4S,5R)-5-Azido-2-chloro-3-(1-ethyl-propoxy)-4-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 195244-46-3 (3S,4R,5S)-4-Amino-5-azido-2-chloro-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 195244-39-4 (3aS,7R,7aS)-4-Chloro-7-hydroxy-2,2-dimethyl-3a,6,7,7a-tetrahydro-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 195244-38-3 (3S,4S,5R)-2-Chloro-3,4,5-trihydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 153919-36-9 methyl 3(S),4(S),5(R)-triacetoxy-2-chloro-1-cyclohexenecarboxylate 

Relevant academic research and scientific papers

Synthesis and activity of C2-substituted analogs of influenza neuraminidase inhibitor GS 4071

The influence of C2-substitution of GS 4071 on the influenza neuraminidase inhibitory activity was investigated. The introduction of lipophilic substituents (chloro, methyl, and methylthio) at the C2 position resulted in a significant decrease of the activity. This result indicates that at the enzyme active site there is limited hydrophobic pocket for a group at the C2 position of GS 4071.