195251-76-4Relevant academic research and scientific papers
Photochemical Rearrangement of Chiral Oxaziridines in Continuous Flow: Application Toward the Scale-Up of a Chiral Bicyclic Lactam
Cochran, John E.,Waal, Nathan
, p. 1533 - 1539 (2016/08/30)
A method for synthesizing chiral lactams from chiral oxaziridines in continuous flow is described. The oxaziridines are readily available from cyclic ketones. Photolysis of the oxaziridines using the Booker-Milburn flow system provides conversion to the chiral lactams in good yield and short residence times. Application of this chemistry toward the synthesis of a chiral bicyclic lactam is described.
Pyrrolopyrazinyl Urea Kinase Inhibitors
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Page/Page column 42, (2010/06/19)
The present invention relates to the use of novel pyrrolopyrazinyl urea derivatives of Formula I, wherein the variables R1, R2, R3, R4, and R5 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.
Asymmetric strecker synthesis of the four α-quaternary 1-amino-2-methylcyclohexanecarboxylic acids
Volk, Franz-Josef,Frahm, August Wilhelm
, p. 1893 - 1903 (2007/10/03)
The synthesis of the four 1-amino-2-methylcyclohexanecarboxylic acids 13, 14, 15, and 16 from diastereomeric mixtures of the α-amino nitriles 1-4 by successive application of conc. H2SO4, Pd/C H2, and conc. HCl is describe
Synthesis of Tridensone, a Sesquiterpene Ketone Isolated from the Liverwort Bazzania tridens. Structure Revision and Absolute Configuration
Tori, Motoo,Kosaka, Kazuhiro,Asakawa, Yoshinori
, p. 2039 - 2042 (2007/10/02)
The title compound and its isomer have been synthesized as optically active forms.The spectral data of the natural compounds 1 were identical with those of our synthetic isomer 1a showing that its structure should be revised and its absolute configuration
ASYMMETRIC SYNTHESIS OF CIS-2-SUBSTITUTED CYCLOHEXANAMINES WITH HIGHT OPTICAL PURITY
Frahm, A. W.,Knupp, G.
, p. 2633 - 2636 (2007/10/02)
Asymmetric reductive amination of racemic 2-substituted cyclohexanones (R= methyl, ethyl, phenyl, benzyl) using optically active 1-phenyl-ethylamines yields optically active cis-cyclohexanamines.
