195305-79-4

Upstream product

• 579-18-0 3-benzoylbenzoic acid 
• 21204-86-4 m-benzoylbenzoic acid methyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 197313-97-6 1-[3-(Dimethoxy-phenyl-methyl)-phenyl]-2,2,2-tris-methylsulfanyl-ethanone 
• 195305-64-7 (3-Benzoyl-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester 
• 195305-52-3 1-(3-Benzoyl-phenyl)-2,2,2-tris-methylsulfanyl-ethanone 
• 467225-74-7 S-butyl bis(butylsulfanyl)(3-benzoylphenyl)thioacetate 
• 467225-78-1 S-butyl α-(3-benzoylphenyl)-α-(butylsulfanyl)thiopropionate 
• 467225-84-9 S-butyl α-(3-benzoylphenyl)thiopropionate 
• 22071-15-4 ketoprofen 

Relevant academic research and scientific papers

8-Aza-11-deoxy prostaglandin analogues

This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: wherein A is a —CH2—CH2—, or —CH═CH—; B is absent, an aryl, or heteroaryl group; R1 is alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and R3, R4, R5 and R6 are not simultaneously hydrogen, or R1 is heterocyclylalkyl, aryl, or heteroaryl when B is absent and R3, R4, R5 and R6 are simultaneously hydrogen; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

Isomerization of Trimethyl α-Keto Trithioorthocarboxylates into α,α-Bis(methylthio) Thiolcarboxylates. A New Rearrangement of Synthetic Interest

A study was made of the isomerization reaction of a great variety of trimethyl α-keto trithioorthocarboxylates to α,α-bis(methylthio) thiolcarboxylates, intermediates of high synthetic value for the synthesis of α-arylpropionic acids. The reaction was carried out in methylene chloride in the presence of catalytic amounts of trityl perchlorate or methanesulfonic acid and was complete in 2 h at rt. In most of the investigated cases the result was positive, the yields usually being greater than 90%. Also the reaction mechanism was subjected to an experimental study.