195310-89-5Relevant academic research and scientific papers
Cyclisation of aminyl radicals derived from amino acids
Bowman, W. Russell,Broadhurst, Michael J.,Coghlan, Daniel R.,Lewis, Kirk A.
, p. 6301 - 6304 (1997)
α-Amino acid aminyl radicals have been generated from sulfenamide precursors using Bu3SnH. The aminyl radicals undergo 5-exo-trig cyclisation reactions onto suitably placed N-alkenyl or α-alkenyl chains on the amino acids with reasonable diastereoselectivity. The α-ester of the amino acid imparts electrophilic behaviour to the aminyl radicals and facilitates cyclisation onto alkenes.
