195314-59-1

Basic information

• Product Name: N-Boc-1,4-cyclohexanediamine
• Synonyms: (4-AMINO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;1-BOC-AMINO-1,4-CYCLOHEXANEDIAMINE;1-N-BOC-1,4-CYCLOHEXANEDIAMINE;N-BOC-1,4-DIAMINECYCLOHEXANE;Trans-N-box-1,4-cyclohexanediamine;BUTYL 4-AMINOCYCLOHEXYLCARBAMATE;Boc-1,4-trans-DACH*HCl;trans-1,4-Diaminocyclohexane, N1-BOC protected
• CAS NO: 195314-59-1
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Product Categories: pharmacetical
• Mol File: 195314-59-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 322.073 °C at 760 mmHg
• Flash Point: 148.585 °C
• Appearance: White/Solid
• Density: 1.029 g/cm³
• Vapor Pressure: 0.000286mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 12.44±0.40(Predicted)
• CAS DataBase Reference: N-Boc-1,4-cyclohexanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-1,4-cyclohexanediamine(195314-59-1)
• EPA Substance Registry System: N-Boc-1,4-cyclohexanediamine(195314-59-1)

Safety Data

• Hazard Codes: Xi,N
• Statements: 51/53
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 195314-59-1(Hazardous Substances Data)

Usage

General Description

N-Boc-1,4-cyclohexanediamine is a chemical compound used in organic synthesis. It is a derivative of cyclohexanediamine, with the addition of a Boc (tert-butoxycarbonyl) protecting group attached to the amine functional group. N-Boc-1,4-cyclohexanediamine is commonly used as a building block in the synthesis of pharmaceutical compounds and as a reagent in organic chemistry reactions. The Boc group serves to protect the amine functionality during the reaction process, allowing for selective manipulation of the molecule. N-Boc-1,4-cyclohexanediamine is an important intermediate in the production of various pharmaceuticals and is a versatile tool in the field of organic synthesis.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9+

Upstream product

• 224309-64-2 tert-butyl N-(4-hydroxycyclohexyl)carbamate 
• 6850-65-3 p-hydroxycyclohexylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2615-25-0 trans-1,4-cyclohexyldiamine 
• 582333-06-0 (4-azido-cyclohexyl)-carbamic acid tert-butyl ester 
• 3114-70-3 trans-1,4-diaminocyclohexane 

Downstream Products

• 866396-80-7 [4-(6-methoxy-3-nitro-pyridin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester 
• 227017-81-4 tert-butyl trans-4-(benzylamino)cyclohexylcarbamate 
• 1011733-35-9 (R)-3-[4-(4-tert-butoxycarbonylamino-cyclohexylamino)-[1,3,5]triazin-2-ylamino]-pyrrolidine-1-carboxylic acid allyl ester 
• 1011483-31-0 (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester 
• 1056938-23-8 C₂₅H₄₂ClN₇O₄ 

Relevant articles and documents

POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE

The present disclosure is directed to compounds of Formula (I) as Bruton's kinase inhibitors and their preparation, as well as compositions comprising compounds of Formula (I).

CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF

Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. Compositions including the compounds having the formula I-A in

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