19535-47-8Relevant academic research and scientific papers
Three thymine/adenine binding modes of the ruthenium complex Λ-[Ru(TAP)2(dppz)]2+ to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography
McQuaid, Kane,Hall, James P.,Baumgaertner, Lena,Cardin, David J.,Cardin, Christine J.
, p. 9116 - 9119 (2019)
Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed from terminal T·A and T·T mismatched pairs. A third shows kinking by a TAP ligand between T·T linkages, while the fourth shows sandwiching of a dppz ligand between a T·A/T·A quadruplex and a T·T mismatch, stabilised by an additional T·A base pair stacking interaction on a TAP surface. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding.
Detection of α-synuclein amyloidogenic aggregates in vitro and in cells using light-switching dipyridophenazine ruthenium(II) complexes
Cook, Nathan P.,Kilpatrick, Kiri,Segatori, Laura,Marti, Angel A.
, p. 20776 - 20782 (2012)
Protein aggregation is the hallmark of a number of neurodegenerative diseases including Parkinson's and Huntington's diseases. There is a significant interest in understanding the molecular mechanisms involved in the self-association and fibrillization of monomeric soluble proteins into insoluble deposits in vivo and in vitro. Probes with novel properties, such as red-shifted emission, large Stokes shifts, and high photostability, are desirable for a variety of protein aggregation studies. To respond to the increasing need for aggregation-responsive compounds suitable to cellular studies, we present a ruthenium(II) dipyridophenazine derivative, [Ru(phen) 2dppz]2+ (phen =1,10-phenanthroline, dppz = dipyrido[3,2-a:2′.3′-c]phenazine), to study aggregation of α-synuclein (αS), which is associated with the development of Parkinson's disease. We demonstrated the use of [Ru(phen)2dppz] 2+ to monitor αS fibril formation in real-time and to detect and quantify αS aggregates in neuroglioma cells, thereby providing a novel molecular tool to study protein deposition diseases in vitro and in vivo.
Mitochondria specific highly cytoselective iridium(iii)-Cp* dipyridophenazine (dppz) complexes as cancer cell imaging agents
Roy, Nilmadhab,Sen, Utsav,Ray Chaudhuri, Shreya,Muthukumar, Venkatesan,Moharana, Prithvi,Paira, Priyankar,Bose, Bipasha,Gauthaman, Ashna,Moorthy, Anbalagan
, p. 2268 - 2283 (2021)
Cancer is the most incurable pernicious disease to date after cardiovascular disease with an immeasurable rate of mortality. However, effective cancer medication and therapy are still castles in the sky to researchers. Therefore, in search of an appropriate strategy to annihilate cancer, we have designed a set of Ir(iii)-Cp* dipyridophenazine complexes as luminescent anticancer agents combining the cancer inhibiting potency of the planar dipyridophenazine (dppz) moiety through DNA interaction and mitochondrial dysfunction with the wonderful photoluminescence ability and target specificity of iridium metal. Hence, with the synergy of these dual aspects in the same system, we have aspired to emphasize the theranostic approach of cancer treatment in the present study by preparing effective, aqueous-soluble, mitochondria-targeting, highly cytoselective, luminescent, cancer cell-permeable scaffolds, enabling diagnosis as well as the healing of cancer cells in the body. Here, the presence of the cyclopentadienyl (Cp*) moiety in association with the fluorine group has boosted the lipophilic character of the complexes. Also, the cytotoxicity screening of the prepared Cp*Ir(iii)-dipyridophenazine complexes (IrL1-IrL7) against colorectal adenocarcinoma cells (Caco-2) and human epitheloid cervix carcinoma cells (HeLa) clearly identified them as potential anticancer agents and imaging studies unveiled their superb cellular imaging properties. Among them, the complex [(η5-Cp*)IrCl(11-fluorodipyrido[3,2-a:2′,3′-c]phenazine)] (IrL6) achieved the best cytoselectivity. However, the superiority of the anticancer potency of [(η5-Cp*)IrCl(benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine)] (IrL3) was also corroborated by its activity against the most aggressive colorectal carcinoma cell line (HT-29), whereas (η5-Cp*)IrCl(11-(trifluoromethyl)dipyrido[3,2-a:2′,3′-c]phenazine (IrL5) came into the limelight as the best theranostic agent as it showed remarkable cytoselectivity as well as significant cellular imaging properties, endowing it with the highest quantum yield value among all the complexes.
Formation of sequence-independent Z-DNA induced by a ruthenium complex at low salt concentrations
Wu, Zhiguo,Tian, Tian,Yu, Junping,Weng, Xiaocheng,Liu, Yi,Zhou, Xiang
, p. 11962 - 11967 (2011)
Switched: The metal complex [Ru(dip)2dppz]2+ can induce the transition from B-DNA to Z-DNA and stabilize the Z conformation in aqueous low-salt solution (see scheme; dip=4,7-diphenyl-1,10-phenanthroline, dppz=dipyridophenazine). The transition is sequence-independent (including non-alternating pyrimidine-purine and AT-rich sequences) and was monitored by CD and 2D NMR spectroscopy, AFM, isothermal titration calorimetry, and gel electrophoresis. Copyright
Crystalline ruthenium polypyridine nanoparticles: A targeted treatment of bacterial infection with multifunctional antibacterial, adhesion and surface-anchoring photosensitizer properties
Yin, Chenyang,Wang, Zekun,Ding, Xiaoyuan,Chen, Xiaoqing,Wang, Jingyuan,Yang, Endong,Wang, Weiyun,Martin, Lisandra L.,Sun, Dongdong
, p. 3808 - 3825 (2021)
Photodynamic antibacterial therapy employs nanocomposites as an alternative to traditional antibiotics for the treatment of bacterial infections. However, many of these antibacterial materials are less effective towards bacteria than traditional drugs, either due to poor specificity or antibacterial activity. This can result in needless and excessive drug use in treatments. This paper describes a multifunctional drug delivery nanoparticle (MDD-NP), Sph-Ru-MMT@PZ, based on the nanostructured-form of [Ru(bpy)2dppz] (PF6)2 (Sph-Ru), which has adhesive properties towards its microbial targets as well as surface-anchoring photosensitizer effects. The design and construction of MDD-NP is based on the adhesive properties of the outer layers of montmorillonite (MMT), which allows Sph-Ru-MMT@PZ to successfully reach its bacterial target; the outer layer of the E. coli. In addition, under 670 nm red irradiation therapy (R-IT), the surface-anchoring properties use the photosensitizer phthalocyanine zinc (PZ) to destroy the bacteria by producing reactive oxygen species (ROS) which causes cell lysis of E. coli. More importantly, Sph-Ru-MMT@PZ has no fluorescence response to live E. coli with intact cell membranes but selectively stained and demonstrated fluorescence during membrane damage of early-stage cells as well as exposure of nuclear materials at late-stage of cell lysis. Sph-Ru-MMT@PZ showed beneficial and synergistic anti-infective effects in vivo by inhibiting the E. coli infection-induced inflammatory response and eventually promoting wound healing in mice. This new strategy for high precision antibacterial therapy towards specific targets, provides an exciting opportunity for the application of multifunctional nanocomposites towards microbial infections.
A series of [Cu(N-N)(P-P)]BF4 complexes: Luminescence quenching caused by electron-configuration transformation in excited state
Zhang, Liming,Yue, Shumei,Li, Bin,Fan, Di
, p. 225 - 232 (2012)
In this paper, we report a series of [Cu(N-N)(P-P)]BF4 complexes based on two phosphorous ligands and three 1,10-phenanthrolin derived diimine ligands, including their syntheses, characterizations, crystal structures. Their photophysical properties were experimentally measured and theoretically analyzed by time-dependent density functional theory (TD-DFT). It is found that the introduction of too many fused phenyl rings into diimine ligand leads to luminescence absence of corresponding [Cu(N-N)(P-P)]+ complexes at room temperature. A detailed analysis suggests that the thermal activated electron-configuration transformation between the [Cu(N-N)(P-P)]+ triplet metal-to-ligand-charge-transfer (3MLCT) state and the lowest lying excited state of its diimine ligand (3LC) is responsible for the luminescence quenching.
Synthesis, structures, DNA-binding, cytotoxicity and molecular docking of CuBr(PPh3)(diimine)
Abdellattif, Magda H.,Alzahrani, Khaled A.,Arshad, Muhammed N.,Asiri, Abdullah M.,Babgi, Bandar A.,Du, Jun,Humphrey, Mark G.,Hussien, Mostafa A.,Mashat, Khlood H.
, (2020)
The copper(I) coordination compounds of general formula [CuBr(PPh3)(N^N)] (N^N = 2,2′-bipyridine (1), 1,10-phenanthroline (2), 4,4′-dimethyl-2,2′-bipyridine (3), 4,4′-dimethoxy-2,2′-bipyridine (4), 3-(2-pyridyl)-4,5-diphenyl-1,2,4-triazine (5),
On the development of a new approach to the design of lanthanide-based materials for solution-processed OLEDs
Kozlov, Makarii I.,Aslandukov, Andrey N.,Vashchenko, Andrey A.,Medvedko, Alexey V.,Aleksandrov, Alexey E.,Grzibovskis, Raitis,Goloveshkin, Alexander S.,Lepnev, Leonid S.,Tameev, Alexey R.,Vembris, Aivars,Utochnikova, Valentina V.
, p. 17298 - 17309 (2019)
The targeted design of lanthanide-based emitters for solution-processed organic light-emitting diodes (OLEDs) resulted in obtaining an NIR OLED with one of the highest efficiencies among ytterbium-based solution-processed OLEDs (30 μW W-1). The design was aimed at the combination of high luminescence efficiency with solubility and charge carrier mobility. The latter was achieved thanks to the introduction of the purposefully selected neutral ligands, which combine electron mobility and the ability to sensitize lanthanide luminescence. Besides, the HOMO and LUMO energies and charge carrier mobility of solution-processed thin films of coordination compounds were measured experimentally for the first time, and novel highly luminescent europium-based materials with PLQYs of up to 80% and purely NIR luminescent ytterbium complexes were obtained.
Ru(ii) photosensitizers competent for hypoxic cancersviagreen light activation
Ballester, Francisco J.,Bautista, Delia,Ortega, Enrique,Ruiz, José,Santana, M. Dolores
, p. 10301 - 10304 (2020)
A family of five heteroleptic complexes [Ru(C^N)(N^N)2][PF6] (HC^N = methyl 1-butyl-2-arylbenzimidazolecarboxylate; N^N = polypyridine) has been synthesized to act as biologically-compatible green light photosensitizers (PSs) with phototherapeutic indexes (PIs) up to higher than 700 under hypoxia (2% O2) in HeLa cancer cells under short time of irradiation.
A luminescent lyotropic liquid-crystalline gel of a water-soluble Ir(III) complex
Aiello, Iolinda,Brunelli, Elvira,Crispini, Alessandra,Ghedini, Mauro,Godbert, Nicolas,La Deda, Massimo,Ricciardi, Loredana,Scarpelli, Francesca
, (2021)
In the present study, the synthesis and properties of a novel water soluble Ir(III) complex of formula [(ppy)2Ir(dpq)]CH3CO2 is described, where ppy is the cyclometalated 2-phenylpyridine ligand and dpq the dipyrido[3,2-f:2′,3′-h]quinoxaline used as ancillary ligand. Own to its specific molecular structure, this complex forms highly ordered supramolecular gels in water on a wide range of concentration, from 3 to 14% w/w. The gel phase shows birefringence under cross polarisers that is completely loss when water is removed, evidence of the formation of a true lyotropic liquid-crystalline gel, without the need of an additional gelator. The gel is macroscopically formed of entangled microfibers that can be seen under optical microscope and that display luminescent properties as observed by confocal microscopy. X-Ray diffraction allowed to resolve the structure of the lyotropic mesophase that is formed by columns of complex cations organised in a tetrahedral manner which are in turn arranged in a larger oblique lattice, hence showing a high degree of order. The photophysical properties of the complex in its different state of matter (solid, gel phase and xerogel) are presented and discussed.
