195375-45-2

Upstream product

• 195375-44-1 1-[(2R,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(trityl-amino)-tetrahydro-furan-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 951-78-0 2'-deoxyuridine 
• 195375-43-0 3'-(Trityl)amino-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyuridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 120625-01-6 1-((2R,4S,5S)-4-azido-5-((tert-butyldimethylsilyloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 76223-04-6 1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 195375-42-9 5'-O-tert-butyldimethylsilyl-3'-amino-2',3'-dideoxyuridine 

Downstream Products

• 195375-46-3 N₄-benzoyl-3'-aminotrityl-2',3'-dideoxycytidine 

Relevant academic research and scientific papers

Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates

The invention provides a method of synthesizing oligonucleotide N3'→P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino

Solid phase synthesis of oligonucleotide N3'-P5' phosphoramidates

The invention provides a method of synthesizing oligonucleotide N3'→P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino

N3′→P5′ Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

A new method for the synthesis of N3′→P5′ phosphoramidate oligodeoxynucleotides is demonstrated. Described herein is the synthesis of the monomers utilized in the phosphoramidite amine-exchange process and the experimental details pertaining to this new mode of chain assembly. The phosphoramidite amine-exchange method generates coupling yields in the 92-95% range per cycle and further enables the synthesis of chimeric phosphoramidate/phosphodiester or phosphoramidate/ phosphorothioate oligonucleotides with no instrument modifications.