1954-28-5

Basic information

• Product Name: etoglucid
• Synonyms: etoglucid;Triethylene glycol diglycidyl ether.;Ethoglucid;2,2'-(2,5,8,11-Tetraoxa-1,12-dodecanediyl)bisoxirane;Epodyl;Etoglucide;ICI-32865;2-[2-[2-(2-glycidoxyethoxy)ethoxy]ethoxymethyl]oxirane
• CAS NO: 1954-28-5
• Molecular Formula: C₁₂H₂₂O₆
• Molecular Weight: 262.34
• EINECS: 217-784-7
• Mol File: 1954-28-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: -15 to -11°
• Boiling Point: bp0.005 140°; bp0.1 133-149°; bp2 195-197°
• Flash Point: 145°C
• Appearance: /
• Density: d20 1.1312
• Vapor Pressure: 6.02E-05mmHg at 25°C
• Refractive Index: nD20 1.4584
• CAS DataBase Reference: etoglucid(CAS DataBase Reference)
• NIST Chemistry Reference: etoglucid(1954-28-5)
• EPA Substance Registry System: etoglucid(1954-28-5)

Safety Data

• Hazardous Substances Data: 1954-28-5(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic byintraperitoneal route. Questionable carcinogen withexperimental neoplastigenic data. A skin irritant. Whenheated to decomposition it emits acrid smoke andirritating fumes.

InChI:InChI=1/C12H22O6/c1(13-3-5-15-7-11-9-17-11)2-14-4-6-16-8-12-10-18-12/h11-12H,1-10H2

Upstream product

• 106-89-8 epichlorohydrin 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 90736-68-8 4,7,10,13-tetraoxahexadeca-1,15-diene 

Downstream Products

• 156366-11-9 1-[2-(2-{2-[2-Hydroxy-3-(4-vinyl-phenoxy)-propoxy]-ethoxy}-ethoxy)-ethoxy]-3-(4-vinyl-phenoxy)-propan-2-ol 

Relevant articles and documents

Polyoxyethylene ether carboxylic acid dimeric surfactant type drag reducer as well as preparation method and application thereof

The invention discloses a polyoxyethylene ether carboxylic acid dimeric surfactant type drag reducer as well as a preparation method and application thereof. The polyoxyethylene ether carboxylic aciddimeric surfactant type drag reducer has a structure formula m=2, 3, 4, and n=1, 2, 3. The drag reducer disclosed by the invention is a dimeric surfactant type drag reducer which has a head group of carboxylic acid, and the head group has the advantages of being very good in temperature resistance, salt resistance, environment protection and the like, and is capable of overcoming influence of a high-salt environment upon drag reduction performance, so that the drag reducer disclosed by the invention is high in drag reduction efficiency, good in shearing resistance, long-lasting and stable in drag reduction rate and good in salt resistance; and polyoxyethylene ether carboxylic acid dimeric surfactants of different mass concentrations are dissolved into water, a drag reduction solution whichis high in drag reduction efficiency, good in shearing resistance, long-lasting and stable in drag reduction rate and good in salt resistance can be prepared without any other compounded chemical reagent, solution blending steps are simple, the drag reducer is very convenient to use, and meanwhile, the salt resistance is greatly improved.

One-pot Three Component Synthesis of ω-(oxathiolan-2-thion-5-yl)-α-oxazolidin-2-ones

We report a practical and one-pot synthesis of novel series of ω-(oxathiolan-2-thione-5-yl)-α- oxazolidin-2-ones (3a-h). The obtained compounds have been designed, synthesized via reaction of oligoethylene glycols diglycidyl ethers, isocyanate and carbon disulfide in the presence of catalytic amount of lithium bromide. A variety of important oxazolidinone derivatives can be obtained from simple starting materials in good yields and the biological activity of these new products will be investigated in complementary study.

Diol glycidyl ether-bridged cyclens: Preparation and their applications in gene delivery

Polymeric 1,4,7,10-tetraazacyclododecanes (cyclens) using diol glycidyl ether with different chain length as bridges (5a-e) were designed and synthesized from various diols, 1,7-diprotected cyclen and epichlorohydrin. The molecular weights of the title polymers were measured by GPC with good polydispersity. Agarose gel retardation and fluorescent titration using ethidium bromide showed good DNA-binding ability of 5. They could retard plasmid DNA (pDNA) at an N/P ratio of 4-6 and form polyplexes with sizes around 100-250 nm from an N/P ratio of 10 to 60 and relatively low zeta-potential values (5-22 mV). The cytotoxicity of 5 assayed by MTT is much lower than that of 20 kDa PEI. In vitro transfection against A549 and 293 cells showed that the transfection efficiency (TE) of 5c/DNA polyplexes is close to that of 20 kDa PEI at an N/P ratio of 5. Structure-activity relationship (SAR) of 5 was discussed in their DNA-binding, cytotoxicity, and transfection studies. The TE of 5c/DNA polyplexes could be improved by the introduction of 50 μM of chloroquine, the endosomolytic agents, to pretreated cells. These studies may extend the application areas of macrocyclic polyamines, especially for cyclen.