1954-45-6

Basic information

• Product Name: 4-METHYL-DL-TRYPTOPHAN
• Synonyms: 2-amino-3-(4-methyl-1H-indol-3-yl)propionic acid;2-azanyl-3-(4-methyl-1H-indol-3-yl)propanoic acid;Tryptophan, 4-methyl-;4-Methyl-DL-tryptophan≥ 98% (HPLC);DL-Trp(4-Me)-OH;DL-(4-METHYL)TRYPTOPHAN;DL-2-AMINO-3-(4-METHYLINDOLYL)PROPIONIC ACID;H-4-ME-DL-TRP-OH
• CAS NO: 1954-45-6
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.25
• EINECS: 217-785-2
• Product Categories: Amino Acids;I - Z;Modified Amino Acids
• Mol File: 1954-45-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 454.1 °C at 760 mmHg
• Flash Point: 228.4 °C
• Appearance: /
• Density: 1.313 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYL-DL-TRYPTOPHAN(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-DL-TRYPTOPHAN(1954-45-6)
• EPA Substance Registry System: 4-METHYL-DL-TRYPTOPHAN(1954-45-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1954-45-6(Hazardous Substances Data)

Usage

Chemical Properties

White to pale white solid

Uses

4-Methyl-DL-tryptophan?is used in preparation of Indolocarbazoles and related compounds as AP-70 kinase inhibitors.

InChI:InChI=1/C12H14N2O2/c1-7-3-2-4-10-11(7)8(6-14-10)5-9(13)12(15)16/h2-4,6,9,14H,5,13H2,1H3,(H,15,16)

Upstream product

• 16096-32-5 4-methyl-1H-indole 
• 302-84-1 serin 
• 164119-68-0 acetylamino-(4-methyl-indol-3-ylmethyl)-malonic acid diethyl ester 
• 6639-59-4 N-(2,3-dimethylphenyl)formamide 
• 164119-81-7 N,N-dimethyl-1-(4-methyl-1H-indol-3-yl)methanamine 

Downstream Products

• 33468-33-6 (R)-2-amino-3-(4-methyl-1H-indol-3-yl)propanoic acid 

Relevant articles and documents

Synthesis method of indole monosubstituted 2-hydroxy-3-(1H-indole-3-yl) propionic acid compound

The invention relates to a synthesis method of an indole monosubstituted 2-hydroxy-3-(1H-indole-3-yl) propionic acid compound, which comprises the following steps of (1) reacting a compound shown as aformula I, DL-serine and acetic anhydride in the presence of a solvent under the protection of inert gas, removing the solvent, and carrying out heat treatment under alkaline conditions to obtain a compound shown as a formula II, (2) under the protection of inert gas, enabling the compound shown in a formula II to react in the presence of nitrite, H2SO4 and water to prepare a compound shown in aformula III, the structural formula of the compound in the formula I being shown in the specification, the structural formula of the compound in the formula II being shown in the specification, the structural formula of the compound in the formula III being shown in the specifications, and in the formulas I, II and III, R being one of alkyl, alkoxy and halogen. Monosubstituted indole and serine are used as raw materials, the indole monosubstituted 2-hydroxy-3-(1H-indole-3-yl) propionic acid compound is prepared through a chemical synthesis method, the raw materials are easy to obtain and cheap, operation is easy, few steps are needed, and the product yield is high.