19541-96-9

Basic information

• Product Name: 5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE
• Synonyms: 3-methyl-1-pyridin-2-yl-1H-pyrazol-5-amine(SALTDATA: FREE);3-methyl-1-(2-pyridinyl)-1H-Pyrazol-5-amine
• CAS NO: 19541-96-9
• Molecular Formula: C₉H₁₀N₄
• Molecular Weight: 174.21
• Mol File: 19541-96-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 363.5 °C at 760 mmHg
• Flash Point: 173.6 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 1.8E-05mmHg at 25°C
• Refractive Index: 1.665
• PKA: 3.28±0.10(Predicted)
• CAS DataBase Reference: 5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE(19541-96-9)
• EPA Substance Registry System: 5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE(19541-96-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19541-96-9(Hazardous Substances Data)

Usage

General Description

5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE is a chemical compound with the molecular formula C11H11N5. It is a pyrazole derivative that contains a pyridinyl amine group. 5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE has potential applications in pharmaceutical research and drug development due to its ability to act as a kinase inhibitor and modulate enzyme activity. It may also have biological activity in the treatment of various diseases and conditions. Further research and studies are likely needed to fully elucidate its pharmacological properties and potential therapeutic uses.

InChI:InChI=1/C9H10N4/c1-7-6-8(10)13(12-7)9-4-2-3-5-11-9/h2-6H,10H2,1H3

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 1118-61-2 3-Aminocrotononitrile 
• 870-64-4 2-aminocrotononitrile 

Downstream Products

• 364727-81-1 2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]-4-nitrobenzoic acid 
• 364727-80-0 2-[[3-Methyl₁-(2-pyridinyl)-1H-pyrazol-5-yl]amino]-5-nitrobenzoic acid 
• 364727-78-6 2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]-5-(trifluoromethyl)benzoic acid 
• 364727-79-7 5-methoxy-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid 
• 1448705-05-2 C₁₆H₁₃F₂N₅O 
• 364728-09-6 2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]nicotinic acid 
• 364727-86-6 4-fluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid 
• 364727-54-8 4-Benzyl-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-6-ol 
• 364727-49-1 6-Benzyl-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-4-ol 
• 364727-83-3 6-chloro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid 
• 364727-85-5 3,5-Dichloro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid 
• 364780-76-7 methyl 4-chloro-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline-6-carboxylate 
• 364727-88-8 methyl 2,3-difluoro-6-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoate 
• 364727-92-4 5-chloro-4-fluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid 

Relevant articles and documents

Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo–Pyrrolo–Pyrazine Scaffolds by Domino Cyclization

Herein, an oxidative ring-opening of 1H-pyrazol-5-amines to form 3-diazenylacrylonitrile derivatives under mild and transition-metal-free conditions is described. In addition, the nucleophilic addition of deprotonated 1H-pyrrole-2-carbaldehydes to the vinyl moiety of the yielded 3-diazenylacrylonitriles could trigger domino cyclization to afford the 3H-pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazine derivatives. Computational studies suggest that the oxidation of 1H-pyrazol-5-amines in the presence of PhIO is through the formation of a hydroxylamine intermediate followed by elimination of H2O to result in the ring-opening product. The detailed domino cyclization pathway leading to the pyrazolo–pyrrolo–pyrazine scaffolds is revealed.

2-(1-HETEROARYLPIPERAZIN-4-YL)METHYL-1,4-BENZODIOXANE DERIVATIVES AS ALPHA2C ANTAGONISTS

Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.

HSP INDUCTOR

An agent for inducing HSP, comprising a compound represented by the formula (I): ???wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, etc.; R2 is absent, a hydrogen atom or a hydrocarbon group which maybe substituted; R3 is a heterocyclic group which may be substituted; X, Y and Z are, respectively, a hydrogen, a halogen, a nitrile, a hydrocarbon group which may be substituted, or X and Y may bind to each other to form ring A, or Y and Z may bind to each other to form ring B; bond portions indicated by a solid line and a broken line are, respectively, a single bond or a double bond, and bond portions indicated by a broken line are, respectively, a single bond or absent; ring A is a homocyclic or heterocyclic 5- to 7-membered ring which may be substituted; ring B is a homocyclic or heterocyclic 5- to 7-membered ring which may be substituted; and n is an integer of 0 or 1, or a salt thereof;