19541-99-2

Usage

Uses

Used in Metabolic Research:
1-Hydroxymethylbenzimidazole is used as a biomarker for [detecting the presence of histidinemia], a rare metabolic disorder. Its role in the metabolism of histidine makes it a valuable tool for understanding and diagnosing this condition.
Used in Vitamin B6 Research:
1-Hydroxymethylbenzimidazole is used as a [vitamin B6 antagonist] for [studying the role of vitamin B6 in various physiological processes]. This application aids researchers in comprehending the importance of vitamin B6 in human health and its potential interactions with other compounds.
Used in Cancer Research and Treatment:
1-Hydroxymethylbenzimidazole is used as a [potential anti-cancer agent] for [inhibiting the proliferation of cancer cells]. Its effectiveness in laboratory studies indicates a promising future in the development of cancer treatments and therapies.

InChI:InChI=1/C8H8N2O/c11-6-10-5-9-7-3-1-2-4-8(7)10/h1-5,11H,6H2

Upstream product

• 51-17-2 benzoimidazole 
• 50-00-0 formaldehyd 

Downstream Products

• 75802-91-4 1-(Chloromethyl)-1H-benzimidazolium chloride 
• 133478-75-8 N-((1H-benzo[d]imidazol-1-yl)methyl)acetamide 
• 51290-77-8 2-(benzylthio)-1H-benzo[d]imidazole 
• 1235-28-5 2-(α-hydroxybenzhydryl)benzimidazole 
• 7152-24-1 2-methylsulfanylbenzimidazole 
• 5028-38-6 2-(4-chloro-α-hydroxybenzyl)benzimidazole 
• 41951-41-1 N-Benzoimidazol-1-ylmethyl-benzamide 
• 50-97-5 (1H-benzimidazol-2-yl)phenylmethanol 
• 63873-98-3 N-benzoimidazol-1-ylmethyl-4-chloro-aniline 
• 63873-92-7 N-benzoimidazol-1-ylmethyl-aniline 

Relevant academic research and scientific papers

Benzazoles 5*. synthesis and arylsulfonylation of 1-hydroxymethylbenzimidazole

1-Hydroxymethylbenzimidazole was synthesized by the reaction of benzimidazole with formaldehyde. Arylsulfonylation of the former in the presence of triethylamine occurred anomalously with deformylation to give 1-arylsulfonylbenzimidazoles in place of the

Highly selective recognition of a-chiral primary organoammonium ions by C3-symmetric peptide receptors

A straightforward synthesis of C3-symmet:ric, imidazole-containing, macrocyclic peptides with different binding arms is presented, The chirality of the backbone and the selection of adequate receptor arms make these systems highly selective receptors for α-chiral primary organoammonium ions. Furthermore, the receptors have the ability to discriminate between enantiomeric guests with selectivity ratios of up to 87:13, The binding constants and the selectivity ratios were estimated by standard 1H NMR titration techniques in CDCl3.

Pyrazolopyrimidines as therapeutic agents

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

Pyrazolopyrimidines as therapeutic agents

The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R2, and R3 are defined as described herein.

Application of ultrasound irradiation for the reactions of N-hydroxymethylation

A convenient and high yield method for the N-hydroxymethylation of substituted phthalimide and benzimidazole under ultrasound irradiation is reported.

A New Synthetic Method for the 2-Substitution of N-Unsubstituted Benzimidazoles: Formaldehyde as a Versatile Protecting Agent for Heterocyclic NH

N-Unsubstituted benzimidazoles 1 are readily converted in a one-pot sequence into 2-substituted derivatives 2 with good overall yields.N-Protection with formaldehyde and lithiation with lithium N,N-diisopropylamide (LDA), n-butyllithium, or tert-butyllithium gives the dilithiohemiaminals 6, which readily react with a range of electrophiles at the 2-carbon.The 2-substituted 1-(lithioxymethyl)benzimidazoles 7 undergo smooth acid-catalyzed dehydroxymethylation under mild conditions to give N-unsubstituted 2-substituted benzimidazoles 2.

A SELECTIVE SYNTHESIS OF UNSYMMETRICAL 1,1'-METHYLENEBISDIAZOLES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS

1,1'-Methylenebisdiazoles Az1-CH2-Az2, Az1 and Az2 being two different diazoles, can be prepared selectively in three steps, through 1-hydroxymethyl- and 1-chloromethyldiazoles, by solid-liquid (S-L) phase transfer catalysis.