195432-92-9

Basic information

• Product Name: 2-Butenedioic acid, 2-[methyl[3-(phenylmethoxy)phenyl]amino]-, dimethyl ester
• CAS NO: 195432-92-9
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol File: 195432-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Butenedioic acid, 2-[methyl[3-(phenylmethoxy)phenyl]amino]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenedioic acid, 2-[methyl[3-(phenylmethoxy)phenyl]amino]-, dimethyl ester(195432-92-9)
• EPA Substance Registry System: 2-Butenedioic acid, 2-[methyl[3-(phenylmethoxy)phenyl]amino]-, dimethyl ester(195432-92-9)

Safety Data

• Hazardous Substances Data: 195432-92-9(Hazardous Substances Data)

Upstream product

• 621-42-1 meta-hydroxyacetanilide 
• 100-44-7 benzyl chloride 
• 190070-39-4 acetic acid-(3-benzyloxy-N-methyl-anilide) 
• 81499-32-3 N-(3-(benzyloxy)phenyl)acetamide 
• 33905-38-3 3-(benzyloxy)-N-methylaniline 
• 762-42-5 dimethyl acetylenedicarboxylate 

Relevant articles and documents

Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists

This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a-b, 13a-k and 19, structurally related to the known potent cysLT1 receptor antagonists RG-12553, IC1-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the evolution of these series leading to antagonists with potency at nanomolar concentrations in vitro.