195457-70-6

Basic information

• Product Name: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID;3'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-CARBOXYLIC ACID;AKOS BAR-0024;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-(TRIFLUOROMETHYL)-;RARECHEM AL BE 1367;4-(3-(Trifluoromethyl)phenyl)benzoic acid
• CAS NO: 195457-70-6
• Molecular Formula: C₁₄H₉F₃O₂
• Molecular Weight: 266.22
• Product Categories: pharmacetical
• Mol File: 195457-70-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 375.7 °C at 760 mmHg
• Flash Point: 181 °C
• Appearance: /
• Density: 1.326 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-70-6)
• EPA Substance Registry System: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-70-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 195457-70-6(Hazardous Substances Data)

Usage

Uses

4-(3-Trifluoromethylphenyl)benzoic Acid is a reagent used in the synthesis of aryl-substituted aspartic acid and diaminopropionic acid derivatives as inhibitors of glutamate transporter EAAT-2 (Excitatory amino acid transporters 2).

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1373523-84-2 (3S)-N-Hydroxy-1-(phenylcarbonyl)-N-(1-{[3'-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine 
• 1373523-83-1 (3S)-N-Ethyl-1-(phenylcarbonyl)-N-(1-{[3'-(trifluoromethyl)biphenyl-4-yl]carbonyl}azetidin-3-yl)pyrrolidin-3-amine 

Relevant articles and documents

PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.

Amide bridged piphenyl or biazaphenyl derivatives

This invention is concerned with compounds of the formula wherein one of R5, R6 and R7 is and R1 to R13, X1, X2, m and n are defined in the description, and all pharmaceutically