195457-71-7

Basic information

• Product Name: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
• Synonyms: AKOS BAR-0023;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID;4-CARBOXY-4'-TRIFLUOROMETHYLDIPHENYL;RARECHEM AL BE 1218;4-(4-(Trifluoromethyl)phenyl)benzoic acid;4''-TRIFLUOROMETHYL-BIPHENYL-4-CARBOXYLIC ACID, 95+%;4'-Trifluoromethyl-biphenyl-4-carboxylic acid
• CAS NO: 195457-71-7
• Molecular Formula: C₁₄H₉F₃O₂
• Molecular Weight: 266.22
• Product Categories: pharmacetical;Biphenyl & Diphenyl ether
• Mol File: 195457-71-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 120.0-121.1 °C
• Boiling Point: 360.769 °C at 760 mmHg
• Flash Point: 171.987 °C
• Appearance: /
• Density: 1.326 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.04±0.10(Predicted)
• CAS DataBase Reference: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-71-7)
• EPA Substance Registry System: 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID(195457-71-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 195457-71-7(Hazardous Substances Data)

Usage

Uses

4''-(Trifluoromethyl)[1,1''-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of pharmaceuticals and pharmaceutical intermediates

Upstream product

• 350792-96-0 (cyclohexyl)(difluoro)[4-(trifluoromethyl)phenyl]silane 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 14047-29-1 4-carboxyphenylboronic acid 
• 619-58-9 4-iodobenzoic acid 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 350792-88-0 (dichloro)(cyclohexyl)[4-(trifluoromethyl)phenyl]silane 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 581-80-6 4,4'-bis(trifluoromethyl)biphenyl 
• 1442121-11-0 N-(2-methoxyethyl)-4-methyl-2-[(1-{[4'-(trifluoromethyl)biphenyl-4-yl]carbonyl}piperidin-4-yl)methyl]-2H-indazole-5-carboxamide 
• 1442120-66-2 4-methyl-N-(2,2,2-trifluoroethyl)-2-[(1-{[4'-(trifluoromethyl)biphenyl-4-yl]carbonyl}piperidin-4-yl)methyl]-2H-indazole-5-carboxamide 
• 1417527-30-0 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1417527-29-7 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1417526-73-8 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1417526-71-6 (4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methanamine 
• 1417526-70-5 3-(azido methyl)-4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazole 
• 1417526-69-2 (4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methanol 
• 1417526-68-1 4-ethyl-3-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazole 
• 1417526-67-0 4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazole-3-thiol 
• 845827-07-8 ethyl 6-({[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate 
• 1187383-81-8 C₂₇H₂₂F₃N₃O 
• 1187383-71-6 C₂₅H₂₂F₃N₃O 

Relevant articles and documents

Solid-phase cross-coupling reaction of aryl(fluoro)silanes with 4- iodobenzoic acid

Aryl(alkyl)(difluoro)silanes undergo a facile and efficient palladium- catalyzed cross-coupling reaction with iodobenzoic acid tethered to the Wang resin. Acid cleavage releases unsymmetrical biaryl carboxylic acids with high conversions, purities, and yields. (C) 2000 Elsevier Science Ltd.

Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives

L-amino alcohol derivatives exhibited high antifungal activity, but the metabolic stability of human liver microsomes in vitro was poor, and the half-life of optimal compound 5 was less than 5 min. To improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of antifungal compounds with a dihydrooxazole scaffold was designed and synthesized. Compounds A33-A38 substituted with 4-phenyl group on dihydrooxazole ring exhibited excellent antifungal activities against C. albicans, C. tropicalis and C. krusei, with MIC values in the range of 0.03–0.25 μg/mL. In addition, the metabolic stability of compounds A33 and A34 in human liver microsomes in vitro was improved significantly, with the half-life greater than 145 min and the half-life of 59.1 min, respectively. Moreover, pharmacokinetic studies in SD rats showed that A33 exhibited favourable pharmacokinetic properties, with a bioavailability of 77.69%, and half-life (intravenous administration) of 9.35 h, indicating that A33 is worthy of further study.

Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies

Fungal infections have became a serious medical problem due to their high incidence and mortality. We describe the discovery and structure-activity relationships studies (SARs) of a series of novel biphenyl imidazole derivatives with excellent antifungal

Palladium-catalyzed cross-coupling reactions of arylsiloxanes with aryl halides: Application to solid-supported organic synthesis

The solid-phase version of the Pd-catalyzed Hiyama reaction between a variety of aryltriethoxysilanes and immobilized aryl halides was developed. Smooth cross-coupling was achieved to afford the corresponding biaryl products in moderate to excellent yields. The described protocol would be particularly useful for the construction of 4′-substituted 1,1′-biphenyl derivatives.