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Pyrido[3,2-d]pyrimidine-2,4-diamine, 6-methyl- is a chemical compound with the molecular formula C10H10N6. It belongs to the class of pyrido[3,2-d]pyrimidines, which are fused heterocyclic compounds consisting of a pyridine ring and a pyrimidine ring. The compound features two amino groups at the 2 and 4 positions, and a methyl group at the 6 position. This specific arrangement of functional groups and the fused ring system contribute to its unique chemical properties and potential applications in various fields, such as pharmaceuticals and materials science.

1955-57-3

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1955-57-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1955-57-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,5 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1955-57:
(6*1)+(5*9)+(4*5)+(3*5)+(2*5)+(1*7)=103
103 % 10 = 3
So 1955-57-3 is a valid CAS Registry Number.

1955-57-3Relevant academic research and scientific papers

Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity

Zhang, Zhili,Wu, Jun,Ran, Fuxiang,Guo, Ying,Tian, Ran,Zhou, Shouxin,Wang, Xiaowei,Liu, Zhenming,Zhang, Liangren,Cui, Jingrong,Liu, Junyi

experimental part, p. 764 - 771 (2009/09/27)

We report, for the first time, the synthesis and biological activities of 8-deaza-5,6,7,8-tetrahydroaminopterin 9, and the 5-substituted and 5,10-disubstituted analogues 11, 13, 15, and 17. The analogues were obtained from key compound diethyl 8-deaza-5,6,7,8-tetrahydroaminopterin 8 following the catalytic reduction of the pyridine ring of diethyl 8-deaza aminopterin 5. The five novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives were assayed in vitro for their cytotoxicity on BGC-823, HL-60, Bel-7402 and Hela tumor cell lines, and inhibition on recombinant human dihydrofolate reductase (DHFR), among which the most potent molecule (compound 9) was about 4- to 10-fold poorer than MTX on the four kinds of tumor cell lines, and its effect on DHFR was about 17-fold poorer than MTX. The docking studies were followed to explain the biological testing results.

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