195519-90-5

Upstream product

• 291520-12-2 [2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzyl ester 
• 380615-22-5 [(2S,3R,5R)-2-Hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzyl ester 
• 172033-24-8 [(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid 
• 128119-39-1 [(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetaldehyde 
• 380615-23-6 [(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzyl ester 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 195519-89-2 2-(3'-deoxythymidin-3'-yl)acetic acid 

Downstream Products

• 291520-13-3 C₅₀H₆₃N₅O₁₂Si 
• 380615-26-9 C₅₆H₆₇N₅O₁₂Si 
• 195519-93-8 N-{(5'S)-3-O-benzyl-3-[(benzyloxy)methyl]-5'-deoxy-5'-ethenylthymidin-5'-yl}-2-[3'-deoxy-5'-O-(dimethoxytrityl)thymidin-3'-yl]acetamide 
• 195519-92-7 N-{(5'R)-3-O-benzyl-3-[(benzyloxy)methyl]-5'-deoxy-5'-ethenylthymidin-5'-yl}-2-[3'-deoxy-5'-O-(dimethoxytrityl)thymidin-3'-yl]acetamide 
• 195519-97-2 C₄₅H₅₁N₅O₁₁ 
• 195519-96-1 C₄₅H₅₁N₅O₁₁ 
• 380615-27-0 N-benzyloxy-2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide 
• 380615-24-7 2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-N-methoxy-acetamide 
• 195519-91-6 [(2S,3R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid pentafluorophenyl ester 

Relevant academic research and scientific papers

Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages

Novel thymidine dimers containing hydroxamate linkages were synthesized, incorporated into oligonucleotide sequences and studied their hybridization properties against complementary DNA and RNA targets.

Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages

Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modified oligonucleotides showed similar binding properties and enhanced resistance to exonucleases compared to natural oligonucleotides. (C) 2000 Elsevier Science Ltd.

114. Aza-claisen rearrangement: Synthesis of 5'-branched 5'- aminothymidines

The syntheses of both diastereoisomers of 5'-ethyl-substituted thymidine dimers, the (5'R)- and (5'S)-configurated 33a and 33b, respectively, in which the natural phosphodiester linkage is replaced by an amide group (C(3')- CH2CONH-CH(5')(Et)), are described. Their fully protected derivatives 35a and 35b, respectively, are suitable for incorporation into antisense oligonucleotides. Unexpectedly, an attempted Pd(II)-catalysed aza-Claisen rearrangement of trichloroacetimidate 7 provided the diastereoisomerically pure cyclopropane derivative 17, whose structure was confirmed by X-ray analysis.