195524-06-2Relevant academic research and scientific papers
A new and rapid access to a 14-membered diketal dilactam ring
Dugat, Denise,Chiaroni, Angele,Riche, Claude,Royer, Jacques,Husson, Henri-Philippe
, p. 5801 - 5804 (2007/10/03)
Macrocyclic dioxadilactam 2 was obtained in two steps from R-(-)-phenylglycinol via the chiral amido-ketal 1. Cyclization of 1 in acidic conditions (PTSA) and concentrated solution (9 = 0.15 M) afforded 2 as three diasteromers 2a+2b+2c, two of which show a C-2 symmetry.
