195528-44-0Relevant articles and documents
Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center
Zhang, Qi,Zhu, Shou-Fei,Cai, Yan,Wang, Li-Xin,Zhou, Qi-Lin
experimental part, p. 1899 - 1906 (2011/02/25)
Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.