195528-46-2

Basic information

• Product Name: 2-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol
• Synonyms: 2-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol
• CAS NO: 195528-46-2
• Molecular Weight: 202.176
• Mol File: 195528-46-2.mol

Chemical Properties

• CAS DataBase Reference: 2-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol(195528-46-2)
• EPA Substance Registry System: 2-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol(195528-46-2)

Safety Data

• Hazardous Substances Data: 195528-46-2(Hazardous Substances Data)

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 107-19-7 propargyl alcohol 
• 199188-30-2 3-(trifluoromethyl)phenyl trifluoromethanesulfonate 
• 107-18-6 allyl alcohol 
• 1428-54-2 rac-2-(3-trifluoromethylphenyl)-oxirane 
• 2181-42-2 trimethylsulphonium iodide 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 1325729-48-3 4,4,5,5-tetramethyl-2-(2-(3-(trifluoromethyl)phenyl)allyl)-1,3,2-dioxaborolane 

Relevant articles and documents

Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles

Conformationally restricted azabicycles are becoming increasingly important in medicinal research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza[3.1.0] and aza[4.1.0] bicycles with excellent enantioselectivity. The key organopalladium species after bicyclization can be trapped by silanes and terminal alkynes.

Copper-Catalyzed Enantiotopic-Group-Selective Allylation of gem-Diborylalkanes

We report a copper-catalyzed enatiotopic-group-selective allylation of gem-diborylalkanes with allyl bromides. The combination of copper(I) bromide and H8-BINOL derived phosphoramidite ligand proved to be the most effective catalytic system to provide various enantioenriched homoallylic boronate esters, containing a boron-substituted stereogenic center that is solely derived from gem-diborylalkanes, in good yields with high enantiomeric ratios under mild conditions. Experimental and theoretical studies have been conducted to elucidate the reaction mechanism, revealing how the enatiotopic-group-selective transmetalation of gem-diborylalkanes with chiral copper complex occurs to generate chiral α-borylalkyl-copper species for the first time. Additional synthetic applications to the synthesis of various chiral building blocks are also included.

Regioselective ring-opening α-methylenation of aryl epoxides to conjugated allyl alcohols utilizing n-BuLi and Me2S=CH2 reagents

In the presence of a mixture of n-BuLi and Me2SCH2 reagents, aryl epoxides underwent a novel ring-opening α-methylenation providing conjugated allyl alcohols with an unusual regioselective pattern.

Highly enantioselective Rh-catalyzed hydrogenation of β,γ- unsaturated phosphonates with chiral ferrocene-based monophosphoramidite ligands

(Chemical Equation Presented) An enantioselective synthesis of chiral alkylphosphonates bearing a β-stereogenic center, based on the Rh-catalyzed asymmetric hydrogenation of corresponding β-substituted β,γ-unsaturated phosphonates with a ferrocene-based monophosphoramidite ligand under the mild hydrogenation conditions, was developed, in which an ee value of up to 98% was obtained.