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DISIALOGANGLIOSIDE GD1B 2NA, also known as Ganglioside GD1b Disodium Salt, is an acidic glycosphingolipid that is a major constituent of neuronal cell membranes and endoplasmic reticulum. It contains two sialic acid residues linked to an inner galactose unit and is involved in modulating cell signal transduction. The concentration of ganglioside GD1b in the human brain increases with age and has been detected in various types of gliomas.

19553-76-5

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19553-76-5 Usage

Uses

Used in Pharmaceutical Industry:
DISIALOGANGLIOSIDE GD1B 2NA is used as a therapeutic agent for the treatment of various types of gliomas, including pilocytic astrocytoma, primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. The application reason is its presence in these tumor types and its potential to modulate cell signal transduction, which may contribute to the development and progression of these cancers.
Used in Research Applications:
DISIALOGANGLIOSIDE GD1B 2NA is used as a research tool for studying the structure, function, and role of gangliosides in neuronal cell membranes and endoplasmic reticulum. The application reason is its ability to modulate intraand intercellular signaling events, which can provide insights into the underlying mechanisms of various neurological disorders and the development of potential therapeutic strategies.
Used in Drug Delivery Systems:
DISIALOGANGLIOSIDE GD1B 2NA can be used as a component in the development of novel drug delivery systems, particularly for targeting cancer cells. The application reason is its ability to form lipid microdomains with cholesterol, which may enhance the delivery, bioavailability, and therapeutic outcomes of anticancer drugs.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Check Digit Verification of cas no

The CAS Registry Mumber 19553-76-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,5,5 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 19553-76:
(7*1)+(6*9)+(5*5)+(4*5)+(3*3)+(2*7)+(1*6)=135
135 % 10 = 5
So 19553-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

19553-76-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name β-Gal-(1→3)-β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1?1')-Cer

1.2 Other means of identification

Product number -
Other names Ganglioside GD1b,disialo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19553-76-5 SDS

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