19555-22-7

Upstream product

• 62-53-3 aniline 
• 62-23-7 4-nitro-benzoic acid 
• 3460-11-5 4-nitrobenzanilide 
• 1614-00-2 (E)-N-(4-nitrobenzylidene)aniline 
• 536-74-3 phenylacetylene 
• 5466-94-4 4-Nitro-N-phenyl-benzimidoyl chloride 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 77951-78-1 N¹-Isobutyryl-4-nitro-N¹,N²-diphenylbenzamidin 
• 77951-74-7 4-Nitro-N¹,N²-diphenyl-N¹-(5,6,7,8-tetrachlor-2-ethyl-2,3-dihydro-3-oxo-1,4-benzodioxin-2-ylcarbonyl)benzamidin 
• 77968-06-0 N¹-(2-Benzyl-5,6,7,8-tetrachlor-2,3-dihydro-3-oxo-1,4-benzodioxin-2-ylcarbonyl)-4-nitro-N¹,N²-diphenylbenzamidin 
• 2769-47-3 4-amino-N,N'-diphenyl-benzamidine 

Relevant academic research and scientific papers

Highly active nano-MgO catalyzed, mild, and efficient synthesis of amidines via electrophilic activation of amides

Nano-MgO catalyzed synthesis of amidine derivatives is developed under solvent-free reaction condition at 70 C. Reusability of the catalyst and shorter reaction time as well as high yields are the advantages of this procedure.

Annulation Reactions with Iron(III) Chloride: Oxidation of Imines

Aromatic imines react with phenylacetylene or styrene in an acetonitrile solution of iron(III) chloride to give quinolines 3 or their tetrahydro derivatives 11 together with variable amounts of products 4 arising from the reduction of the imines.The initial step appears to be a one-electron oxidation to generate iron(II) and an imine radical cation.When the reactions are carried out in the presence of stoichiometric amounts of tetrachloro-p-benzoquinone (chloranil), only quinolines 3 are obtained.

Synthesis of Amides and Amidines by Reaction of Carboxylic Acids and Amines in the Presence of Polyphophoric Acid Trimethylsilyl Ester (PPSSE)

The reaction between amines and carboxylic acids in the presence of poliphosphoric acid trimethylsilylester (PPSE) has been investigated from the view point of the synthesis of amides and amidines.Benzanilide was selectively prepared from benzoic acid and aniline in the presence of PPSE and pyridine at 100 degC, whereas a mixture of benzanilide and N,N'-diphenylbenzamidine was obtained without the use of pyridine.The reaction at 160 degC almost exclusively gave N,N'-diphenylbenzamidine.Various simmetrical amidines were obtained from combinations of carboxylic acids and aromatic amines in high yields by simply heating at 160 degC with four molar amounts of PPSE.The reactions of aliphatic and aromatic amines with N-monosubstituted and N,N-disubstituted amides also afforded corresponding unsymmetrical amidines under the same conditions.The reaction mechanism is discussed in some detail.

A NOVEL DIRECT SYNTHESIS OF AMIDINES FROM CARBOXYLIC ACIDS AND AMINES USING POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE) AS CONDENSING AGENT

It was found that amidines were obtained directly by the reaction of carboxylic acids with amines in the presence of PPSE, and the yields of amidines were dependent on the structure of amines rather than that of carboxylic acids.