19557-97-2

Upstream product

• 108-94-1 cyclohexanone 
• 1904-58-1 anthranilic acid hydrazide 
• 118-48-9 isatoic anhydride 

Relevant academic research and scientific papers

Synthetic method of quinazolinone Schiff base compounds

The invention discloses a synthetic method of quinazolinone Schiff base compounds. The synthetic method comprises the following steps: 1, raw materials including isatoic anhydride, carbonyl containing compounds and hydrazine hydrate are weighed in the mole ratio being 1:(2-2.2):1; 2, the raw materials weighed in the step 1 are mixed in a solvent, and the mixture is subjected to a heating reflux reaction with a nanometer metal oxide as a catalyst; 3, reaction products obtained in the step 2 are separated and purified, and the quinazolinone Schiff base compounds are obtained. With the adoption of the synthetic method, poisonous solvents and acid and alkaline conditions used in current synthetic reactions are avoided, reaction steps are reduced, and the reaction yield is increased.

An efficient nano CuO-catalyzed synthesis and biological evaluation of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones as potent antibacterial agents against Streptococcus lactis

An environmentally benign nano CuO catalyzed strategy has been developed for one-pot synthesis of quinazolinone Schiff base derivatives and bis-2,3-dihydroquinazolin-4(1H)-ones by use of hydrazine hydrate and ethidene diamine as nitrogen source. The antib

Synthesis of new 3,4-di-and 1,2,3,4-tetrahydroquinazolin-4-one derivatives and X-ray diffraction study of crystal solvates of 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one

The reactions of hydrazide, mesyl hydrazide, succinyl hydrazide, and maleyl hydrazide of anthranilic acid with carbonyl compounds were studied, and new di-and tetrahydroquinazolin-4-one derivatives were prepared. The structure of one reaction product, viz., 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one, was established by X-ray diffraction study of two crystal solvates of this compound. The characteristic features of the crystal packings of these solvates are discussed. Springer Science+Business Media, Inc. 2006.

Formation of 1,2-Dihydroquinazolin-4(3H)-ones. Reinvestigation of a Recently Reported 1,3,4-Benzotriazepine Synthesis

A recent paper (Bull.Chem.Soc.Jpn. 59, 1575/1986/) reported that the reactions of o-aminobenzoylhydrazine with benzylideneanilines lead to the formation of 1,3,4-benzotriazepin-5-one or 1-(o-benzylideneaminobenzoyl)-2-benzylidenehydrazines, depending on the substituents used.This is shown by the present paper to be incorrect.Depending on the proportions of the reagents, the above reactions lead to 1-(o-aminobenzoyl)-2-benzylidenehydrazines (7) or 2-aryl-3-benzylideneamino-1,2-dihydroquinazolin-4(3H)-ones (8).