195609-22-4Relevant academic research and scientific papers
Selective sodium channel regulator as well as preparation and application thereof
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Paragraph 0148; 0150-0153, (2021/02/10)
The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.
Approaches to 1,1-disubstituted cinnolin-3-ylio oxides: Synthesis and reactivity of a new class of heterocyclic betaines
Aran, Vicente J.,Asensio, Juan L.,Molina, Jose,Munoz, Pilar,Ruiz, Jose R.,Stud, Manfred
, p. 2229 - 2235 (2007/10/03)
The cinnolin-3-ylio oxides 6, a new class of heterocyclic aminimide, can be prepared by intramolecular cyclization of the N′,N′-disubstituted (2-fluorophenyl)acetohydrazides 5. Attempts to prepare these betaines by an alternative route, namely cyclization of the nitrenes expected from the thermal decomposition of (2-dialkylaminophenyl)acetyl azides 11, failed, Curtius rearrangement-derived compounds being the main products isolated from these processes. Hydrochlorides of the cinnolin-3-ylio oxides 6 undergo alkyl halide elimination to yield the 1-(ω-chloroalkyl)cinnolin-3-ols 19a,b or 1-methylcinnolin-3-ol 21. Oxidation of the latter to the 3-hydroxycinnolin-4-one 22, its methylation to the corresponding N1,O-23 and N1,N2-dimethyl 24 derivatives as well as the cyclization of 1-(5-chloropentyl)cinnolin-3-ol 19a to the diazepino[1,2-a]cinnolinone 20 are also reported.
