19579-63-6Relevant academic research and scientific papers
Chiral Silver Alkoxide Catalyzed Asymmetric Aldol Reaction of Alkenyl Esters with Isatins
Yanagisawa, Akira,Kawada, Aiko
supporting information, p. 1246 - 1252 (2021/05/05)
A catalytic enantioselective aldol reaction of alkenyl esters with isatins was achieved using a DM-BINAP·AgOTf complex as the chiral precatalyst and N, N -diisopropylethylamine as the base precatalyst in the presence of methanol or 2,2,2-trifluoroethanol.
Chiral copper compound as well as preparation method and application thereof
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Paragraph 0091-0092; 0108-0112, (2020/07/28)
The invention provides a chiral copper compound with a structure as shown in a general formula (I), a preparation method of the chiral copper compound and application of the chiral copper compound tosynthesis of chiral 3-hydroxy-2-oxoindole compounds, wherein Ar in the general formula (I) represents a phenyl group or a substituted phenyl group, and substituent groups in the substituted phenyl group are respectively one or more of C1-C5 alkyl groups, C1-C5 alkoxy groups and C1-C5 fluoroalkyl groups. The chiral copper compound has the advantages that the asymmetric Mukaiyama Aldol reaction of the isatin compound can be efficiently catalyzed; the 3-hydroxy-2-oxoindole compound can be obtained with high enantioselectivity and diastereoselectivity, and the stereoselectivity of the product canstill be maintained when the chiral copper compound is utilized to amplify the reaction to the gram-level scale. The asymmetric Mukaiyama Aldol reaction catalyzed by the compound has good tolerance towater.
C U 2O-Catalyzed C(SP 3)-H/C(SP 3)-H Cross-Coupling Using TEMPO: Synthesis of 3-(2-Oxoalkyl)-3-hydroxyoxindoles
Wang, Baoshuang,Zhu, Jiayi,Wei, Yang,Luo, Guotian,Qu, Hongen,Liu, Liang-Xian
, p. 2841 - 2848 (2015/12/23)
A simple, convenient, and efficient oxidative cross-coupling reaction of oxindoles with ketones toward a variety of 3-(2-oxoalkyl)-3-hydroxyoxindoles in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative cross-coupling by using 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) in air as an environmentally benign oxidant. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of oxindoles.
Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 A as additive
Chen, Wen-Bing,Liao, Yu-Hua,Du, Xi-Lin,Zhang, Xiao-Mei,Yuan, Wei-Cheng
experimental part, p. 1465 - 1476 (2010/05/18)
In the presence of molecular sieve (MS) 4 A in DMF, a catalyst-free aldol condensation of a variety of aromatic and aliphatic ketones with isatins under mild reaction conditions has been developed. This approach may provide access to a wide range of 3-sub
Potential Anticonvulsants. III. The Condensation of Isatin with Cyclic Ketones
Popp, F. D.,Parson, R.,Donigan, B. E.
, p. 1329 - 1330 (2007/10/02)
Isatin has been condensed with a series of cyclic ketones to give 3-substituted-3-hydroxyoxindoles as potential anticonvulsants.
