195872-03-8

Upstream product

• 16837-38-0 nicotinic anhydride 
• 1080-06-4 L-Tyr-OMe 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 195872-47-0 11-Iodo-undecanoic acid 4-{(S)-2-methoxycarbonyl-2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl ester 
• 1360608-03-2 N-nicotinoyl-O-(4-acetoxybenzoyl)-L-tyrosine methyl ester 
• 1360607-99-3 N-nicotinoyl-O-(2,5-dimethoxybenzoyl)-L-tyrosine methyl ester 
• 1360607-98-2 N-nicotinoyl-O-(2,4-dimethoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-01-0 N-nicotinoyl-O-(3-methoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-02-1 N-nicotinoyl-O-(4-methoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-00-9 N-nicotinoyl-O-(2-methoxybenzoyl)-L-tyrosine methyl ester 
• 1360607-97-1 N-nicotinoyl-O-(2,3-dimethoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-05-4 N-nicotinoyl-O-(2-hydroxy-4-methoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-06-5 N-nicotinoyl-O-(2,5-dihydroxybenzoyl)-L-tyrosine methyl ester 
• 1360608-07-6 N-nicotinoyl-O-(2-hydroxy-5-methoxybenzoyl)-L-tyrosine methyl ester 
• 1360608-08-7 N-nicotinoyl-O-(2-hydroxybenzoyl)-L-tyrosine methyl ester 
• 1360608-09-8 N-nicotinoyl-O-(3-hydroxybenzoyl)-L-tyrosine methyl ester 
• 1360608-04-3 N-nicotinoyl-O-(2,3-dihydroxybenzoyl)-L-tyrosine methyl ester 

Relevant academic research and scientific papers

Synthesis of nicotinamide derivatives having a hydroxy-substituted benzene ring and the influence of their structures on the apoptosis-inducing activity against leukemia cells

With the view of developing novel apoptosis-inducing agents against malignant cells, nicotinamide derivatives containing substituted O-benzoyl-tyrosine, dopamine, and norepinephrine residues were synthesized. Antiproliferative activity measurements using leukemia U937 cells revealed that the benzoyl-tyrosine derivative having two hydroxys at C-2 and C-3 on the benzoyl group, and the one having a hydroxy at C-2 and a methoxy at C-4 proved the most potent among the 9 nicotinamide derivatives. The IC50 values of these compounds were 0.87 and 3.15 μM, which indicates their noteworthy activity compared with epigallocatechin gallate, a catechin component in green tea known for its noticeable activity. The cell death process was confirmed to be the result of apoptosis by agarose gel electrophoresis and dye staining, suggesting the high potential of these compounds as apoptosis-inducing anticancer agents. Drug Dev Res 72: 289-297, 2011.

Synthesis of 1,3-Linked 1,4-Dihydropyridines Containing the L-Tyrosine Residue and the Influence of their Structures Upon the Enantioselective Reduction

Novel 1,3-linked chiral 1,4-dihydropyridines (5a-c) bearing the L-tyrosine residue and the long alkyl chains have been synthesized.The ring size gave a large influence upon the enantioselective reduction of methyl benzoylformate, where 1,12-oxo-2,20-diaza