195877-55-5

Basic information

• Product Name: 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 195877-55-5
• Molecular Weight: 390.48
• Mol File: 195877-55-5.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester(195877-55-5)
• EPA Substance Registry System: 4-(2-benzyloxycarbonylamino-3-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester(195877-55-5)

Safety Data

• Hazardous Substances Data: 195877-55-5(Hazardous Substances Data)

Upstream product

• 195877-49-7 4-[(S)-2-Azido-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 195877-48-6 4-[3-(4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 195877-52-2 4-(2-azido-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 195877-50-0 S-2-azido-3-(N-Boc-piperidyl)-propionic acid 
• 195877-53-3 4-(2-amino-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 154775-43-6 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid 
• 84228-93-3 3-(pyridin-4-yl)acrylic acid 
• 1822-32-8 3-(4-piperidyl)propionic acid 
• 195877-54-4 tert-butyl 4-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl]piperidine-1-carboxylate 

Downstream Products

• 1001647-40-0 C₂₈H₃₅N₃O₆ 
• 195877-57-7 4-(2-benzyloxycarbonylamino-3-hydroxy-3-methoxycarbonyl-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 195877-56-6 4-(3-acetoxy-2-benzyloxycarbonylamino-3-cyano-propyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Compounds and Compositions as Channel Activating Protease Inhibitors

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

2-Amino-3-piperidin-4-yl-propionic acid containing peptidomimetics are potent protease inhibitors when combined with an appropriate keto-thiazole or keto-carboxylic acid moiety. A novel P1 residue in factor Xa and thrombin inhibitors has been found resulting in IC50 values as low as 0.048 μM, a factor of ten more potent than Argatroban. Starting with non-chiral synthetic routes, a new stereospecific route was developed as well as a new solid- phase method.