195885-13-3Relevant academic research and scientific papers
One-pot reaction for the synthesis of N-substituted 2-aminobenzoxazoles using triphenylbismuth dichloride as cyclodesulfurization reagent
Murata, Yuki,Matsumoto, Natsuho,Miyata, Maya,Kitamura, Yuki,Kakusawa, Naoki,Matsumura, Mio,Yasuike, Shuji
, p. 18 - 23 (2018/02/09)
The treatment of various 2-aminophenols with isothiocyanates afforded thioureas, which were reacted in situ with triphenylbismuth dichloride in the presence of triethylamine to give the expected N-substituted benzoxazol-2-amines in good to excellent yields. Triphenylbismuth dichloride promoted the successful cyclodesulfurization of thioureas with short reaction times under mild reaction conditions. This reaction is the first example of the synthesis of heterocyclic rings using a pentavalent organobismuth reagent.
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
Song, Hyunmin,Oh, Sei-Ryang,Lee, Hyeong-Kyu,Han, Gyoonhee,Kim, Joo-Heon,Chang, Hyeun Wook,Doh, Kyung-Eun,Rhee, Hee-Kyung,Choo, Hea-Young Park
experimental part, p. 7580 - 7585 (2011/01/04)
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compoun
