19590-22-8 Usage
Chemical compound
17-cyano-5,16-androstadien-3 beta-ol-3-acetate is a chemical compound that falls under the category of androgens.
Androgens
Androgens are typically associated with the male sex hormone testosterone.
Androstane derivative
17-cyano-5,16-androstadien-3 beta-ol-3-acetate is an androstane derivative.
Cyano group
The compound has a cyano group at the 17-position.
Hydroxyl group
The compound has a hydroxyl group at the 3-beta position.
Acetate ester
The compound has an acetate ester at the 3-position.
Pharmacological effects
17-cyano-5,16-androstadien-3 beta-ol-3-acetate has been studied for its potential pharmacological effects.
Hormonal balance
The compound has the ability to modulate hormonal balance.
Muscle growth and development
The compound has the potential to influence muscle growth and development.
Endocrinology
The compound may have potential applications in the field of endocrinology.
Hormone replacement therapy
The compound may have potential applications in hormone replacement therapy.
Further research
Further research and clinical studies are needed to fully understand the full range of effects and potential uses of 17-cyano-5,16-androstadien-3 beta-ol-3-acetate.
Check Digit Verification of cas no
The CAS Registry Mumber 19590-22-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,5,9 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19590-22:
(7*1)+(6*9)+(5*5)+(4*9)+(3*0)+(2*2)+(1*2)=128
128 % 10 = 8
So 19590-22-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H29NO2/c1-14(24)25-17-8-10-21(2)15(12-17)4-6-18-19-7-5-16(13-23)22(19,3)11-9-20(18)21/h4-5,17-20H,6-12H2,1-3H3/t17-,18-,19-,20-,21-,22+/m0/s1
19590-22-8Relevant academic research and scientific papers
Synthesis, structural, computational, and antiproliferative activity studies of new steroidal tetrazole derivatives
Jakimov, Dimitar S.,Klisuri?, Olivera R.,Oklje?a, Aleksandar M.,Rai?evi?, Vidak N.
, (2022/02/17)
Herein, we report the synthesis of five new tetrazole-tethered steroids (5–9), analogues of the prostate cancer drug abiraterone. All newly prepared compounds were characterized by 1H and 13C NMR spectroscopy and high-resolution mass
Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives.
Zhu,Ling, Yangzhi,Lei, Xiaoping,Handratta, Venkatesh,Brodie, Angela M H
, p. 603 - 611 (2007/10/03)
Twelve 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androsta-5,16-diene derivatives were designed and synthesized from 3 beta-acetoxy-pregna-5,16-dien-20-one (1b) as inhibitors of 17 alpha-hydroxylase-C(17,20)-lyase (P450(17 alpha)). Potent inhibitors of this enzyme could be of value as treatment of prostate cancer. Two substituents (methyl and phenyl) were introduced either at their 4'- or 5'-position in order to investigate their structure-activity relationship. Due to the 16,17-double bond, 17-thiazoles were generally obtained in low yield. The pharmacological results showed that the compounds containing 17-(2'-oxazolyl) (14c) and 17-(2'-thiazolyl) (8c) (41.5%) demonstrated reasonable inhibition against P450(17 alpha). Their 3-acetate (13c and 7c) were less potent than their 3-OH counterparts. The introduction of a phenyl or methyl group generally decreased inhibitory activity. Surprisingly, 17-(5'-methyl-2'-thiazolyl) (12a) was the most potent compound in this series and was almost as potent as L-39, which has good antitumor activity.
