195970-40-2

Upstream product

• 1429-59-0 1,2-distearoyl-sn-glycerol 
• 108549-21-9 benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite 
• 112-76-5 Stearoyl chloride 
• 56586-08-4 3-O-benzyl-1,2-dioctadecanoyl-sn-glycerol 
• 4145-51-1 3-O-Benzyl-1-O-octadecanoyl-sn-glycerin 

Downstream Products

• 1273157-13-3 2-O-(benzyloxy-1,2-di-O-stearoyl-sn-glycero-3-phosphoryl)-1,3-bis-(3,4,6-tri-O-benzyl-2-O-methoxycetyl-α-D-mannopyranosyl)glycerol 
• 852395-69-8 1-O-((2R)-benzyl-1,2-di-O-stearoyl-sn-glycero-3-phosphoryl)-2-O-[6-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-2,3,4-tri-O-benzyl-α-D-mannopyranosyl]-1,2-ethanediol 
• 852395-84-7 2-O-(benzyloxy-1,2-di-O-stearoyl-sn-glycero-3-phosphoryl)-1,3-bis-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)glycerol 
• 852395-74-5 (1R,2R)-1-O-(benzyl-1,2-di-O-stearoyl-sn-glycero-3-phosphoryl)-2-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)cylcohexane-1,2-diol 

Relevant academic research and scientific papers

Efficient asymmetric synthesis of phosphatidyl-D-myo-inositol 3,4,5- trisphosphate

Phosphatidyl-D-myo-inositol 3,4,5-trisphosphate, a candidate of the second messenger in cellular signal transduction, was efficiently synthesized in a homochiral form.

Development of isotope-enriched phosphatidylinositol-4- And 5-phosphate cellular mass spectrometry probes

Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPnmetabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the development of a divergent synthetic route applicable to the synthesis of deuterated PtdIns4Pand PtdIns5Pderivatives. The synthetic strategy developed involves a key enzymatic desymmetrisation step using Lipozyme TL-IM. In addition, we optimised the large-scale synthesis of deuteratedmyo-inositol, allowing for the preparation of a series of saturated and unsaturated deuterated PtdIns4Pand PtdIns5Pderivatives. Experiments in MCF7 cells demonstrated that these deuterated probes enable quantification of the corresponding endogenous phospholipids in a cellular setting. Overall, these deuterated probes will be powerful tools to help improve our understanding of the role played by PtdInsPnin physiology and disease.

SYNTHETIC MOLECULES HAVING IMMUNE ACTIVITY

The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosaccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.

Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase

Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.