195984-33-9

Upstream product

• 195984-32-8 (R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-2,5-dione 

Downstream Products

• 195985-82-1 (3R)-7-Cyano-1,2,3,5-tetrahydro-N,N-dimethyl-3-(phenylmethyl)-4H-1,4-benzodiazepine-4-sulfonamide 
• 195984-91-9 (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195985-72-9 (R)-7-Cyano-2,3,4,5-tetrahydro-3-(phenylmethyl)-4-(propylsulfonyl)-1H-1,4-benzodiazepine 
• 195985-38-7 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-4-(thien-2-ylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195985-69-4 (R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195987-08-7 (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-[(1,1-dimethylethoxy)carbonyl]-1H-1,4-benzodiazepine-7-carbonitrile 
• 1026414-72-1 (R)-7-cyano-4-[(2-chloroethyl)sulfonyl]-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4H-1,4-benzodiazepine 
• 195987-41-8 BMS-214662 
• 195984-90-8 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile 

Relevant academic research and scientific papers

Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4- (2-thienysulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

Continuing structure-activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and a 4-s

Inhibitors of farnesyl protein transferase

The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.