196081-79-5

Basic information

• Product Name: 5-BROMOINDOLE-3-ACETAMIDE
• Synonyms: 5-BROMOINDOLE-3-ACETAMIDE;2-(5-BROMO-1H-INDOL-3-YL)-ACETAMIDE;5-BROMOINDOLE-3-ACETAMIDE 98% (HPLC);5-BROMOINDOLE-3-ACETAMIDE (5BrIAM);2-(5-bromo-1H-indol-3-yl)ethanamide
• CAS NO: 196081-79-5
• Molecular Formula: C₁₀H₉BrN₂O
• Molecular Weight: 253.1
• Product Categories: Indoles and derivatives
• Mol File: 196081-79-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 517.5 °C at 760 mmHg
• Flash Point: 266.8 °C
• Appearance: /
• Density: 1.668 g/cm³
• Vapor Pressure: 8.18E-11mmHg at 25°C
• Refractive Index: 1.711
• CAS DataBase Reference: 5-BROMOINDOLE-3-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOINDOLE-3-ACETAMIDE(196081-79-5)
• EPA Substance Registry System: 5-BROMOINDOLE-3-ACETAMIDE(196081-79-5)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 196081-79-5(Hazardous Substances Data)

Usage

Uses

5-Bromoindole-3-acetamide can be used for discovery and optimization of small-mol. ligands for CBP/p300 bromodomains. Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

InChI:InChI=1/C10H9BrN2O/c11-7-1-2-9-8(4-7)6(5-13-9)3-10(12)14/h1-2,4-5,13H,3H2,(H2,12,14)

Upstream product

• 774-14-1 (5-bromo-1H-indol-3-yl)-acetonitrile 
• 40432-84-6 (5-bromo-1H-indol-3-yl)-acetic acid 
• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY

The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same.

Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 2: SAR of the amine tether

A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin-dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to >20 μM and were dependant upon both the nature of the aryl group and the tether joining the basic amine to the indolyl maleimide core. Key interactions with the kinase ATP site and hinge region, predicted by homology modeling, were confirmed.

INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE

The present invention relates, in general, to isoprenylcysteine carboxyl methyltransferase (Icmt) and, in particular, to inhibitors of Icmt and to methods of disease treatment using same.