196094-23-2

Upstream product

• 196094-12-9 (3S,4R,5R)-5-(3-Benzyloxy-propyl)-1-(4-methoxy-benzyl)-3,4-bis-triisopropylsilanyloxy-pyrrolidin-2-one 
• 196094-14-1 (3S,4R,5R)-1-(4-Methoxy-benzyl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-3,4-bis-triisopropylsilanyloxy-pyrrolidin-2-one 
• 196094-21-0 {(1R,2R,3R,4S)-2,3,4-Tris-benzyloxy-1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-hex-5-enyl}-carbamic acid tert-butyl ester 
• 196094-15-2 (3S,4R,5R)-3,4-Bis-benzyloxy-1-(4-methoxy-benzyl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-pyrrolidin-2-one 
• 196094-13-0 (3S,4R,5R)-5-(3-Hydroxy-propyl)-1-(4-methoxy-benzyl)-3,4-bis-triisopropylsilanyloxy-pyrrolidin-2-one 
• 196094-20-9 {(1R,2R,3R,4S)-2,3-Bis-benzyloxy-1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-hydroxy-hex-5-enyl}-carbamic acid tert-butyl ester 
• 196094-19-6 (2R,3R,4S)-3,4-Bis-benzyloxy-2-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 196094-16-3 (3S,4R,5R)-3,4-Bis-benzyloxy-5-(3-hydroxy-propyl)-1-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 196094-18-5 (3S,4R,5R)-3,4-Bis-benzyloxy-5-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-pyrrolidin-2-one 
• 196094-30-1 (3S,4R,5R)-3,4-Dihydroxy-1-(4-methoxy-benzyl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-pyrrolidin-2-one 
• 196094-17-4 (3S,4R,5R)-3,4-Bis-benzyloxy-5-(3-hydroxy-propyl)-pyrrolidin-2-one 
• 196094-22-1 {(1R,2R,3S,4S)-2,3,4-Tris-benzyloxy-1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5,6-dihydroxy-hexyl}-carbamic acid tert-butyl ester 

Downstream Products

• 115649-93-9 1-deoxy-castanospermine 
• 196094-26-5 (2R,3R,4R,5S)-3,4,5-Tris-benzyloxy-2-(3-hydroxy-propyl)-piperidine-1-carboxylic acid benzyl ester 
• 133521-24-1 3-((2R,3R,4R,5S)-3,4,5-Tris-benzyloxy-piperidin-2-yl)-propan-1-ol 

Relevant academic research and scientific papers

Stereocontrolled Synthesis of a Trihydroxylated Indolizidine Alkaloid, 1-Deoxycastanospermine

An efficient and novel process is described for the asymmetric synthesis of (6S,7R,8R,8aR)-6,7,8-trihydroxyindolizidine alkaloid, 1-deoxycastanospermine in 22% overall yield based on the C2-imide featuring the completely stereoselective reduction of an α-hydroxypyrrolidine intermediate elaborated through asymmetric deoxygenation of a quaternary α-hydroxylactam.