196103-67-0

Upstream product

• 403-21-4 3-fluoro-4-nitrobenzoic acid 
• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 
• 541-16-2 t-butyl malonate 
• 196103-66-9 methyl 4-nitro-3-(((trifluoromethyl)sulfonyl)oxy)benzoate 

Downstream Products

• 1037834-32-4 di-tert-butyl [2-amino-5-(methoxycarbonyl)phenyl]malonate 
• 1037834-33-5 di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-5-(methoxycarbonyl)phenyl]malonate 
• 1037834-36-8 benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate 
• 1037834-35-7 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-2-oxoindoline-5-carboxylic acid 
• 1037834-34-6 methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate 

Relevant academic research and scientific papers

INHIBITORS OF SERINE PALMITOYLTRANSFERASE

This invention provides compounds of the formula (I) useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

Leukotriene antagonistic benzoic acid derivatives

The invention relates to benzoic acid derivatives being leukotriene antagonists. The compounds therefore are suitable as active ingredients in medicaments particularly in medicaments for the treatment of respiratory diseases.