19614-16-5

Basic information

• Product Name: 2-Bromothioanisole
• Synonyms: 2-BROMOTHIOANISOLE;2-BROMOPHENYL METHYL SULFIDE;1-BROMO-2-(METHYLTHIO)BENZENE;O-BROMOTHIOANISOLE;TIMTEC-BB SBB006566;1-Bromo-2-(methylsulfanyl)benzene;o-Bromo(methylthio)benzene;o-Bromophenyl methyl sulfide
• CAS NO: 19614-16-5
• Molecular Formula: C₇H₇BrS
• Molecular Weight: 203.1
• EINECS: 243-183-4
• Product Categories: Miscellaneous;Thioderivates
• Mol File: 19614-16-5.mol
• Article Data: 26

Chemical Properties

• Melting Point: -24 °C
• Boiling Point: 145-146 °C (27 mmHg)
• Flash Point: >110°C
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.522 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0217mmHg at 25°C
• Refractive Index: 1.632-1.634
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 2243716
• CAS DataBase Reference: 2-Bromothioanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromothioanisole(19614-16-5)
• EPA Substance Registry System: 2-Bromothioanisole(19614-16-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26
• RIDADR: UN 3334
• WGK Germany: 3
• HazardClass: IRRITANT, STENCH
• Hazardous Substances Data: 19614-16-5(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

Uses

2-Bromothioanisole has been used in the preparation of:thioether-methyleneborane (PhSCH2B (C6F5)2)21-dimesitylboryl-2-methylthio-benzene

InChI:InChI=1/C7H7BrS/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 1072-85-1 o-fluorobromobenzene 
• 40920-16-9 methyl dithiopivalate 
• 74-88-4 methyl iodide 
• 7133-37-1 cyclohexyl methyl sulfide 
• 2568-36-7 6,6-dibromobicylo[3.1.0]hexane 
• 75-15-0 carbon disulfide 
• 7726-95-6 bromine 
• 137092-17-2 2-Bromo-benzenediazonium; hydrogen sulfate 
• 126218-83-5 1-bromo-2-(methylsulfinyl)benzene 
• 75-18-3 dimethylsulfide 
• 583-55-1 1-Bromo-2-iodobenzene 
• 624-92-0 Dimethyldisulphide 
• 124-38-9 carbon dioxide 

Downstream Products

• 99346-83-5 1,2-bis(bis(2-methylthiophenyl)phosphino)ethane 
• 126218-83-5 1-bromo-2-(methylsulfinyl)benzene 
• 118362-17-7 C₁₄H₁₄BrNO₂S₂ 
• 74449-35-7 methyl o-methylthiophenyl selenide 
• 108543-19-7 2'-methylthio-1,1,1,3,3,3-hexafluoro-2-phenylpropan-2-ol 
• 30439-31-7 1-(2-Methylsulfanyl-phenyl)-ethanol 
• 166831-65-8 2,2,2-trifluoro-1-(2-methylsulfanylphenyl)ethanone 
• 1620-95-7 [2-(methylthio)phenyl](phenyl)methanone 
• 32250-83-2 1-(2-Methylsulfanyl-phenyl)-1-phenyl-ethanol 
• 33951-33-6 1-bromo-2-(methylsulfonyl)benzene 
• 7321-58-6 (S)-methyl o-bromophenyl sulfoxide 
• 7321-58-6 (R)-2-bromophenyl methyl sulfoxide 
• 14092-00-3 methyl o-tolyl sulfide 
• 135-13-7 (o-carboxyphenyl)thioacetic acid 

Relevant articles and documents

SUBSTITUTED 3,4,12,12A-TETRAHYDRO-1H-[1,4]OXAZINO[3,4-C]PYRIDO[2,1-F][1,2,4]TRIAZINE-6,8-DIONE, PHARMACEUTICAL COMPOSITION, AND METHODS FOR PREPARING AND USING SAME

Influenza is an acute infectious respiratory disease caused by the influenza virus. It is part of the group of Acute Respiratory Viral Infections (ARVI). It occasionally spreads in the form of epidemics and pandemics. Currently, more than 2000 variants of the influenza virus differing in the antigen spectrum have been identified. Given that influenza is a serious threat to public health (worldwide, these annual epidemics lead to 3-5 million cases of severe illness, millions of hospitalizations, and up to 650,000 deaths), it seems appropriate to search for new anti-influenza drugs with improved characteristics. The inventors surprisingly found out that the previously unknown substituted 3,4,12,12a-tetrahydro-1 H-[1,4] oxazino[3,4-c]pyrido[2,1-f] [1,2,4]triazine-6,8-dione of general formula 1, its stereoisomer, their prodrug, pharmaceutically acceptable salt, solvate, hydrate, and a crystalline or polycrystalline form thereof are effective agents for prophylaxis and treatment of viral diseases, including influenza where R1 is (6,7-difluoro-5,10-dihydrothieno[3,2-c][2]benzothiepin-10-yl, (7,8-difluoro-4,9-dihydrothieno[2,23-c][2]benzothiepin-4-yl, (3,4-difluorophenyl)(phenyl)methyl, (3,4-difluorophenyl)(2-methylsulfanylphenyl)methyl, diphenylmethyl, bis(4-fluorophenyl)-methyl; R2 is hydrogen or a protective group selected from a series comprising (C1-C3 alkyl) oxycarbonyloxy, {[(C1-C3 alkyl)oxycarbonyl]-oxy}methoxy, {[2-(C1-C3 alkyl) oxyethoxy]carbonyl}oxy, ({[(1R)-2-[(C1-C3alkyl)oxy]-1-methylethoxy}carbonyl)oxy, {[(3S)-ethoxyfuran-3-yloxy]-carbonyl}oxy, [(ethoxy-2H-pyran-4-yloxy)carbonyl]oxy,{[(1-acetylazetidine)-3-yloxy]carbonyl}oxy, {[(C1-C3alkyl) oxycarbonyl] -oxy}methoxy, ({[2-(C1-C3 alkyl)oxyethoxy]carbonyl}oxy) methoxy.

t-BuOK-promoted methylthiolation of aryl fluorides with dimethyldisulfide under transition-metal-free and mild conditions

In the presence of potassium tert-butoxide (t-BuOK), the cross-coupling reaction between aryl fluorides and dimethyldisulfide was developed. A series of aryl methyl sulfides were obtained in moderate to good yields under transition-metal-free and mild conditions.

Reduction of CO2 with NaBH4/I2 for the Conversion of Thiophenols to Aryl Methyl Sulfides

We report a tandem reaction to realize reduction of carbon dioxide with thiophenols to generate aryl methyl sulfides under the NaBH4/I2 system with 18-crown-6 as the solvent. Thiophenols bearing electron-donating and electron-withdrawing groups are feasible in this reaction. Controlled experiment results indicate that 18-crown-6 plays a critical role in six-electron reduction of carbon dioxide.