196200-68-7

Upstream product

• 50-89-5 thymidine 
• 196200-60-9 5'-O-(4-4'-dimethoxytrityl)-3'-O-levulinoyl-N³-pivaloyloxymethylthymidine 
• 196200-64-3 4-Oxo-pentanoic acid (2R,3S,5R)-5-[3-(2,2-dimethyl-propionyloxymethyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2-methylsulfanylmethoxymethyl-tetrahydro-furan-3-yl ester 
• 196200-62-1 4-Oxo-pentanoic acid (2R,3S,5R)-5-[3-(2,2-dimethyl-propionyloxymethyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2-hydroxymethyl-tetrahydro-furan-3-yl ester 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 93134-37-3 5'-O-(4,4'-dimethoxytrityl)-3'-O-levulinoyl-2'-deoxythymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 196200-66-5 C₃₈H₅₄N₄O₁₇ 
• 196200-65-4 C₅₀H₈₂N₄O₁₇Si₂ 

Downstream Products

• 196200-70-1 C₆₈H₈₂ClN₄O₂₂P 

Relevant academic research and scientific papers

Design and synthesis of a possible mimic of a thrombin-binding DNA aptamer

A synthesis is presented of the cyclic trimeric d-oligonucleotide 3'-isopropylphosphate I, comprising one formacetal and two (3' → 5')-internucleosidic phosphodiester bonds. The ester linkages connect d-guanosine with the 3' and 5' ends of thymidine and 5-hydroxymethyl-2'-deoxyuridine-3'-isopropylphosphate (HMDUpiPr), respectively. The 5'-end of the thymidine unit is anchored via the formacetal bond to the allylic hydroxyl group of HMDUpiPr. The cyclic arrangement of the three d-nucleosides in I mimics, as based on molecular modeling, the key structural features of the conformationally constrained T7pG8pT9p-domain of the thrombin-binding DNA aptamer d(G1G2T3T4G5G6T7G8T9G10G11T12T13G14G15). Biological evaluation showed that compound I did not exhibit anti-thrombin activity.