196202-01-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2,2-DIFLUORO-3-OXOPENTANOATE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the formation of complex molecular structures that are integral to the development of new drugs.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, METHYL 2,2-DIFLUORO-3-OXOPENTANOATE serves as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of molecules that are vital for the creation of effective crop protection agents.
Used as a Solvent and Reactant in Organic Chemistry:
METHYL 2,2-DIFLUORO-3-OXOPENTANOATE is also utilized as a solvent and reactant in various chemical processes, capitalizing on its unique properties to facilitate specific reactions and improve the efficiency of organic synthesis.

InChI:InChI=1/C11H12F6O/c12-10(13,14)9(18,11(15,16)17)5-8-4-6-1-2-7(8)3-6/h1-2,6-8,18H,3-5H2

Upstream product

• 30414-53-0 methyl propanoyl acetate 

Relevant academic research and scientific papers

Electrophilic fluorination with N,N′-difluoro-2,2′-bipyridinium salt and elemental fluorine

NNpm-Difluoro-22pm-bipyridiniu m bis(tetrafluoroborate) (MEC-31) was shown to be a highly reactive electrophilic fluorinating agent with the highest effective fluorine content in its class. We have developed the perfect recycled fluorination system with MEC-31 for the lower-cost industrial fluorination and for an environment. MEC-31 can be completely recycled including the counter-anion. We found the fluorination of 2-naphthol in liquid CO2 with MEC-31 in the presence of catalytic amount of NaOTf proceeded quantitatively without the generation of by-product. In the fluorination of 1,3-dicarbonyl compounds with elemental fluorine, we found the introduction method of fluorine gas would be very important in order to make a reaction efficient. As fluorination goes on, the quantity of 1,3-dicarbonyl compounds of the starting material is reduced gradually, and therefore the quantity of fluorine must be reduced by the method to control the flow rate or the concentration of fluorine gas diluted with nitrogen, together the fluorination to proceed efficiently.

PROCESS FOR PRODUCING 2-FLUORO-3-OXOALKYLCARBOXYLIC ACID ESTER

A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3wt% or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.

Fluorination of methyl 3-oxopentanoate (MOP) using difluorobis(fluoroxy)methane, BDM

Difluorobis(fluoroxy)methane, BDM, is an electrophilic fluorinating agent that is capable of affecting selective monofluorination of 1,3-dicarbonyls such as diketones and ketoesters with very high regioselectivity. For example, in highly acidic anhydrous HF (AHF) solvent, fluorination of methyl 3-oxopentanoate (MOP) with BDM provides methyl 2-fluoro-3-oxopentanoate (MFOP) with 100% conversion and 95% selectivity. In mixtures of HF and methanol, fluorination conversions and selectivity are markedly lower. In comparison, direct fluorination of MOP with dilute F2 typically affords a fluorinated product that is less pure, being contaminated with radical fluorination byproducts that are difficult to separate. Fluorination of MOP with dilute mixtures of BDM and F2 is generally more selective than using dilute F2 alone.