196204-46-3Relevant academic research and scientific papers
A comparison of the antiviral activity of 2-aminoarylthioalcenols and their derivatives: Isothiocyanates, thioureas
Raux,Sauleau,David,Sauleau,Boustie,Amoros,Girre
, p. 301 - 304 (2007/10/03)
On the basis of our previous studies concerning aminoarylthioalcenols, the selective transformation of the NH2 moiety into isothiocyanates is described. The scope and limitations of the thiourea synthesis was further investigated through the reaction of isothiocyanates with hydrazine hydrate. Depending on solvents used, the reaction did not afford thioureas but gave unexpected pyrazoles and hydrazones. The structures of all new products were established on the basis of their spectral data. For some of the new compounds, the antiviral activity was evaluated against an RNA-virus (poliovirus) and a DNA-virus (herpes simplex virus type 1). As only thiourea compounds showed any antiviral activity against both viruses, the thiourea moiety appeared to be crucial for this activity.
