19626-82-5Relevant academic research and scientific papers
An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols
Graton, Jerome,Wang, Zhong,Brossard, Anne-Marie,Goncalves Monteiro, Daniela,Le Questel, Jean-Yves,Linclau, Bruno
supporting information; experimental part, p. 6176 - 6180 (2012/08/14)
Rewriting the rules as fluorination does not always increase hydrogen-bond acidity: while the strongly electron-withdrawing fluorine significantly enhances alcohol H-bond acidity in anti-vicinal fluorohydrins, an intramolecular F...HO interaction overrule
